Discover and read the best of Twitter Threads about #flozinate
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📢📢Tweetorial Alert📢📢 1/14
What are the benefits of Sodium-Glucose Cotransporter-2 inhibitors (SGLT2i)?
What are the benefits of Sodium-Glucose Cotransporter-2 inhibitors (SGLT2i)?
All of the above?
#Flozinators we know #flozins are great & are beneficial in CKD & CV disease, but do they really prevent kidney stones?
How do they work? Does it have anything to do with their effects on magnesium or uric acid? Does the presence of DM make a difference?
#Flozinators we know #flozins are great & are beneficial in CKD & CV disease, but do they really prevent kidney stones?
How do they work? Does it have anything to do with their effects on magnesium or uric acid? Does the presence of DM make a difference?
Stone formation risk ↑ in DM:
↑ uric acid excretion💎
Impaired ammoniagenesis
↓ in urinary pH levels
Dehydration with urinary concentration 🥤
@Momen_Abbasi
renalfellow.org/2023/02/19/kid…
↑ uric acid excretion💎
Impaired ammoniagenesis
↓ in urinary pH levels
Dehydration with urinary concentration 🥤
@Momen_Abbasi
renalfellow.org/2023/02/19/kid…
1) Welcome to a new #accredited (0.75h CE/#CME) #tweetorial on challenging case presentations for pts with #cardiometabolic disease, #CaReMe #FOAMed.
Our expert author is Claire Davies. @claireyrivs is a specialist diabetes & endocrinology #pharmacist working in Gateshead in 🇬🇧.
Our expert author is Claire Davies. @claireyrivs is a specialist diabetes & endocrinology #pharmacist working in Gateshead in 🇬🇧.
2) She is a member of UKCPA Diabetes & Endocrinology committee @UKCPADiabetes & works across #diabetes, #endocrinology, & emergency/acute care in Secondary Care. She is currently involved in development of regional guidelines & education to support medicines optimisation for PLWD
3a) This program is intended for healthcare professionals and is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company.
1a) Welcome to one of our favorite events on the @academiccme #accredited #tweetorial feeds: a takeover of our programming from @GoggleDocs! The focus of this tweetorial is data from #ADA2022 on #SGLT2i beyond cardiac disease. Our expert author is @GoggleDocs' @drpatrickholmes.
1b) Check out our other #ADA2022 recap #tweetorial by new @GoggleDocs family member @Ines_VFonseca who focused on the cardiac data presented: ckd-ce.com/dkd13_ada22a/
2) This program is #accredited for CE/#CME #physicians #physicianassociates #nurses #pharmacists #nursepractitioners & is supported by an educational grant from the Boehringer Ingelheim Pharmaceuticals Inc and Eli Lilly Company. It is intended for healthcare professionals.
1) Welcome to a new #accredited #tweetorial, Prevention and Management of Heart Failure in T2 Diabetes: The Cardiologist’s Perspective! Our expert author is Giuseppe Galati MD, MMSc in Heart Failure, @GiuseppeGalati_ , Consultant #Cardiologist #HeartFailure & #Cardiomyopathies
2) @GiuseppeGalati_ is at San Raffaele Research Hospital, Milan 🇮🇹 @SanRaffaeleMI. This program is intended for #healthcare professionals & is accredited for 0.75h CE/#CME credit for #physicians #physicianassistants #nurses #nursepractitioners #pharmacists 🇺🇸🇨🇦🇬🇧🇪🇺.
3) @cardiomet_CE is supported by educational grants from AstraZeneca, Bayer, Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company, & Chiesi. Earn credit from archived programs at cardiometabolic-ce.com. Disclosures at cardiometabolic-ce.com/disclosures/.🙏 FOLLOW US !
SLGT2i and the Kidney Tweetorial Part 2
Start: Time to #flozinate
When prescribing- mindful for bp management kidney360.asnjournals.org/content/2/4/74… @aishaikh
Start: Time to #flozinate
When prescribing- mindful for bp management kidney360.asnjournals.org/content/2/4/74… @aishaikh
What about Scrt... SGLT2i therapy can cause an acute drop in eGFR. In the absence of hemodynamic instability or an alternate cause of AKI, the initial decline in GFR by 4-8 ml/min/1.73m2 after SGLT2i initiation is likely due to reduction in intra-glomerular pressure.
A typical patient included in CREDENCE would lose 4.6 ml/min/year of eGFR if treated with RAASi only, reaching ESKD in 10 years. However, if canagliflozin is added to his treatment, he would only lose 1.85 ml/min/year of eGFR, delaying ESKD by 15 kidney360.asnjournals.org/content/early/…
Post Grand Rounds SLGT2i and the Kidney Tweetorial
- The Glucoretics - thanks @edgarvlermamd @ChristosArgyrop @jam_hirsch for some slides
Start...PART 1 nature.com/articles/s4158…
- The Glucoretics - thanks @edgarvlermamd @ChristosArgyrop @jam_hirsch for some slides
Start...PART 1 nature.com/articles/s4158…
SGLT2 is responsible for reabsorbing up to 90% (animal data) of the glucose filtered at the glomerulus. The remaining 10% (animal data) is reabsorbed by SGLT1 that is expressed on the luminal (brush border) surface of cells of the S3 segment of the proximal tubule
Pathophysiology of Diabetic Nephropathy and role of SGLT2
Join here tomorrow for the launch of a new accredited tweetorial on the expanding role of #SGLT2i in CV disease! Earn 0.5 CE/CME credits: physicians, nurses, pharmacists! Expert faculty @mvaduganathan. #medtwitter @academiccme #diabetesmanagement @endocrinenetwrk
1) Welcome to a Tweetorial on #SGLT2i & CV health. “Flozinators of the world, unite!” Accredited for 0.50h by @academiccme: #physicians, #nurses, #pharmacists. I am @mvaduganathan . . .
. . . and this educational activity, which is intended for healthcare providers, is supported by grants from Abbott, AstraZeneca, Bayer, Chiesi, and NovoNordisk.
1/ #NYACP #Tweetorial
#MedTwitter, let’s start with a ❓
56 yo man with type 2 diabetes mellitus and CAD for 7 years has a A1C 8.0%, and albumin:creatinine ratio 300. Which add-on diabetes med will have a protective effect on his cardiac comorbidities?
@MedTweetorials
#MedTwitter, let’s start with a ❓
56 yo man with type 2 diabetes mellitus and CAD for 7 years has a A1C 8.0%, and albumin:creatinine ratio 300. Which add-on diabetes med will have a protective effect on his cardiac comorbidities?
@MedTweetorials
2/ That’s right- Canagliflozin!
In this tweetorial we address: Why are we optimistic about SGLT2 inhibitors?
♦️ The -flozins let glucose “flow out: of proximal convoluted tubules of nephrons
♦️ Half of filtered glucose is excreted- more than 💯g in T2DM patients
#flozinate
In this tweetorial we address: Why are we optimistic about SGLT2 inhibitors?
♦️ The -flozins let glucose “flow out: of proximal convoluted tubules of nephrons
♦️ Half of filtered glucose is excreted- more than 💯g in T2DM patients
#flozinate
3/ Okay, they work for T2DM. But so do all7⃣of our first line agents! Why all the hype?
SGLTi also:
✅ ⬇️ risk of cardiovascular mortality in chronic and decompensated failure
✅ Slow progression of diabetic and non-diabetic kidney disease
✅ Induce weight loss ⚖️
SGLTi also:
✅ ⬇️ risk of cardiovascular mortality in chronic and decompensated failure
✅ Slow progression of diabetic and non-diabetic kidney disease
✅ Induce weight loss ⚖️
