Discover and read the best of Twitter Threads about #drugpricing
Most recents (18)
So what are #PBMs? Chances are, if your meds suddenly got changed by your insurer, or you’ve been waiting weeks on #priorauth for a med you need, or you pay $$$$$ for a drug in the US that is cheap overseas, you’ve already experienced a #PBM and didn’t even know… twitter.com/i/web/status/1…
That’s b/c #PBMs aren’t meant to be known, they’re meant to be a middleman in healthcare cutting in an extra layer of profit for them and an extra cost to you…wonder why #prescriptiondrug pricing makes no sense compared to prices in other countries? This is why.
Pharmacy Benefit Managers (PBMs) are third party entities paid by healthcare insurance companies to manage all things meds: the formulary (what is/isn’t covered), the price from manufacturer, and the cost (copay or “tier”) to the patient.
🧵When resources are limited, the question of what knowledge is needed and when — the ‘decision gate’ analogy — becomes the principal strategic consideration in determining the priority of activities during early drug development
@NatRevDrugDisc #biotech
nature.com/articles/nrd11…
@NatRevDrugDisc #biotech
nature.com/articles/nrd11…
Evidence showing ligands & receptors to be variable and discerning instigators of signals, and translators of information, respectively, have illustrated the fallacy of assuming that the surrogate host cell is an inert vessel-Terry Kenakin @NatRevDrugDisc
nature.com/articles/nrd11…
nature.com/articles/nrd11…
Stepping back from the rather safe HTS paradigm to discovery in virtual space which is still not yet fully developed, certainly needs courageous management decisions not only in terms of financial investments, but also in organizational evolution @Aalanine
nature.com/articles/nrd10…
nature.com/articles/nrd10…
As promised, a 🧵 on GoodRx.
Starting off with the basics…
What is it?
GoodRx is a prescription drug price tracking and discount company. It’s essentially another middle man in the messy landscape that is #drugpricing in the US.
But it’s more complicated than that… #TwitteRx
Starting off with the basics…
What is it?
GoodRx is a prescription drug price tracking and discount company. It’s essentially another middle man in the messy landscape that is #drugpricing in the US.
But it’s more complicated than that… #TwitteRx
GoodRx is best known for their coupons. They track prescription drug prices and offer patients a discounted price, which varies a bit based on which pharmacy you select.
Here’s an example of what a search for enalapril looks like…
2/17
Here’s an example of what a search for enalapril looks like…
2/17
GoodRx coupons CANNOT be combined with insurance. ❌
Now, this *might* be helpful for a patient who is completely uninsured, or someone on relatively few inexpensive meds who never hits their deductible anyway, but even then, if you ask your pharmacist for a cash price instead…
Now, this *might* be helpful for a patient who is completely uninsured, or someone on relatively few inexpensive meds who never hits their deductible anyway, but even then, if you ask your pharmacist for a cash price instead…
#CDC has scheduled an emergency meeting of #ACIP for Dec. 1 to vote on which groups of Americans should receive the limited initial doses of the #COVID19 #vaccines once those products are cleared for the U.S. market.
BREAKING: Promoting Effectiveness And Equity As COVID-19 Vaccines And Treatment Emerge.
Today, we focus on #COVID19 #vaccines & treatment. Amidst recent news of successful vaccine trials & new treatments, we highlight key policy + regulatory issues: bit.ly/2UJBxlg (1/9)
Today, we focus on #COVID19 #vaccines & treatment. Amidst recent news of successful vaccine trials & new treatments, we highlight key policy + regulatory issues: bit.ly/2UJBxlg (1/9)
This set of fast-track ahead-of-print journal articles kicks off with @AKesselheim of @BrighamWomens et al's paper, which explores #vaccine development, approval, and regulation as well as tradeoffs in balancing safety, efficacy, and speed: bit.ly/3pJySGM (2/9)
How successful will new #vaccines be? While more effective vaccines always lead to better outcomes, the story gets complex when you start to vary the parameters. @jasonlschwartz & @ADPaltiel from @YaleSPH w/ coauthors from @harvardmed investigate: bit.ly/33gugyj
THREAD: Are we using ACEIs & ARBs properly? A TI Tweetorial
1/6: British Columbia doctors give 4.5m scripts/year for ACE inhibitors (ACEIs) & angiotensin receptor blockers (ARBs) to control bp. Goal is to ↘️ mortality & morbidity, not simply to ↘️ bp.
#MedEd #hypertension
1/6: British Columbia doctors give 4.5m scripts/year for ACE inhibitors (ACEIs) & angiotensin receptor blockers (ARBs) to control bp. Goal is to ↘️ mortality & morbidity, not simply to ↘️ bp.
#MedEd #hypertension
2/6 BEST EVIDENCE on ARBs & ACEI for #hypertension
3⃣@CochraneHTN systematic reviews:
ACEs v ARBs for htn bit.ly/34vS0hu
BP lowering efficacy of ACEIs for htn bit.ly/30YNIOX
BP lowering efficacy of ACEIs for htn https://t.co/u8dN378QAe
#MedEd
3⃣@CochraneHTN systematic reviews:
ACEs v ARBs for htn bit.ly/34vS0hu
BP lowering efficacy of ACEIs for htn bit.ly/30YNIOX
BP lowering efficacy of ACEIs for htn https://t.co/u8dN378QAe
#MedEd
3/6 ACEIs over ARBS when considering HARMS 🤔
Both ACEIs & ARBs ↘️ blood pressure to similar extents.... BUT only ACEIs have evidence for a reduction in risk of morbidity & mortality. So they’d be your first choice 🥇
#MedEd #medsafety #ptsafety
Both ACEIs & ARBs ↘️ blood pressure to similar extents.... BUT only ACEIs have evidence for a reduction in risk of morbidity & mortality. So they’d be your first choice 🥇
#MedEd #medsafety #ptsafety
THREAD: Are we using ACEIs & ARBs properly? A TI Tweetorial
1/6: British Columbia doctors give 4.5m scripts/year for ACE inhibitors (ACEIs) & angiotensin receptor blockers (ARBs) to control bp. Goal is to ↘️ mortality & morbidity, not simply to ↘️ bp.
#MedEd #hypertension
1/6: British Columbia doctors give 4.5m scripts/year for ACE inhibitors (ACEIs) & angiotensin receptor blockers (ARBs) to control bp. Goal is to ↘️ mortality & morbidity, not simply to ↘️ bp.
#MedEd #hypertension
2/6 BEST EVIDENCE on ARBs & ACEI for #hypertension
3⃣@CochraneHTN systematic reviews:
ACEs v ARBs for htn bit.ly/34vS0hu
BP lowering efficacy of ACEIs for htn bit.ly/30YNIOX
BP lowering efficacy of ACEIs for htn https://t.co/NCl1dfCCAO
#MedEd
3⃣@CochraneHTN systematic reviews:
ACEs v ARBs for htn bit.ly/34vS0hu
BP lowering efficacy of ACEIs for htn bit.ly/30YNIOX
BP lowering efficacy of ACEIs for htn https://t.co/NCl1dfCCAO
#MedEd
3/6 ACEIs over ARBS when considering HARMS 🤔
Both ACEIs & ARBs ↘️ blood pressure to similar extents.... BUT only ACEIs have evidence for a reduction in risk of morbidity & mortality. So they’d be your first choice 🥇
#MedEd #medsafety #ptsafety
Both ACEIs & ARBs ↘️ blood pressure to similar extents.... BUT only ACEIs have evidence for a reduction in risk of morbidity & mortality. So they’d be your first choice 🥇
#MedEd #medsafety #ptsafety
So #drugpricing twitter is going to be all abuzz about SCOTUS discussing PBMs. But let's be clear - this case isn't about drug prices and PBMs in the way we usually think about them. 1/7
statnews.com/pharmalot/2020…
statnews.com/pharmalot/2020…
Instead, it's about whether the state can mandate higher payments for less competitive pharmacies. The community pharmacy lobby complained that they weren't getting paid enough, and the state put in a law to protect them. 2/7
Community pharmacies can't purchase generic drugs at the same extreme discounts as larger purchasers. When PBMs use the average acquisition cost of drugs to reimburse pharmacies, that average can be below what community pharmacies paid to buy the drugs. 3/7
Day one today of @OversightDems #drugprices hearing at 10amET: $BMY & its Celgene unit & $TEVA.
oversight.house.gov/legislation/he…
Also, at 11:30amET, @EnergyCommerce #COVID19 #vaccines hearing: energycommerce.house.gov/committee-acti…
oversight.house.gov/legislation/he…
Also, at 11:30amET, @EnergyCommerce #COVID19 #vaccines hearing: energycommerce.house.gov/committee-acti…
.@RepMaloney notes that anyone in the @OversightDems room not wearing #masks will not be recognized at today's #drugpricing hearing.
#drugprices $BMY $TEVA
#drugprices $BMY $TEVA
.@RepMaloney starts out playing clip of @RepCummings, who died last year before he could convene today's #drugpricing hearing.
He notes #pharma one of most powerful/profitable industries in the world.
#DrugPrices #pharma #biotech
He notes #pharma one of most powerful/profitable industries in the world.
#DrugPrices #pharma #biotech
More allegations emerged that political appointees in the Trump administration have been attempting to interfere with and impose influence on the scientific work of federal agencies to downplay the severity of #COVID19, which has killed nearly 200,000 Americans.
#CDC #FDA #NIH
#CDC #FDA #NIH
Meanwhile, after waiting seven weeks for Trump to reveal the text of his so-called most favored nations executive order for the Medicare Part B program, he revoked the July 24 order on Sept. 13 and replaced it with an amended version, seeking to include the Part D program.
Executive orders simply instruct federal agencies to take certain actions. But the orders have limited authority, can be difficult to enforce without legislation, take months, if not years, to implement and can easily be challenged in court.
#drugprices #drugpricing #pharma
#drugprices #drugpricing #pharma
The U.S. House Oversight Committee to subpoena drugmaker, AbbVie, after it refused to cooperate with the Congressional investigation into their #drugpricing practices surrounding Humira and Imbruvica. 1/3
AbbVie filed a 165 patent applications to protect Imbruvica from generic competition. Additional patent protections led to nine additional years of monopoly and $41 billion in spending on this drug. i-mak.org/imbruvica/ 2/3
For its blockbuster Humira, AbbVie filed 247 patent applications blocking generic competition for nearly 40 years. Since its launch, Humira's price has increased substantially with no justification: i-mak.org/humira/ 3/3
.@PhRMA spox to me just now: "We are not aware of any meeting."'
So, what was that Trump was saying today ...
#DrugPrices #DrugPricing #pharma #biotech
So, what was that Trump was saying today ...
#DrugPrices #DrugPricing #pharma #biotech
Recall when all those industry executives exited Trump's advisory committees after #Charlottesville, with CEO one of the last to exit.
Since then, many CEOs, including J&J, have returned to White House, attended Trump events.
Given his recent remarks, are they still eager?
Since then, many CEOs, including J&J, have returned to White House, attended Trump events.
Given his recent remarks, are they still eager?
.@PhRMA @steveubl recently was in #JacksonHole with Ivanka & Jared fundraising for Republicans in midst of #COVID19 #pandemic.
What are the optics risks now for #pharma when any Trump event is a wildcard?
What do CEOs think about Trump's recent remarks about #KyleRittenhouse?
What are the optics risks now for #pharma when any Trump event is a wildcard?
What do CEOs think about Trump's recent remarks about #KyleRittenhouse?
And still sitting today.
reginfo.gov/public/do/eoDe…
And still no text of Trump's "favored nations" #drugpricing executive order.
federalregister.gov/presidential-d…
EOs have limited authority, are difficult to enforce, take months/years to implement & can easily be challenged in court.
reginfo.gov/public/do/eoDe…
And still no text of Trump's "favored nations" #drugpricing executive order.
federalregister.gov/presidential-d…
EOs have limited authority, are difficult to enforce, take months/years to implement & can easily be challenged in court.
And International Pricing Index Model For Medicare Part B Drugs proposed rule still pending.
reginfo.gov/public/do/eoDe…
Still no sight of Trump's favored nations EO text
federalregister.gov/presidential-d…
And @PhRMA said no #drugprices meetings it's aware of this week, despite Trump's claim
reginfo.gov/public/do/eoDe…
Still no sight of Trump's favored nations EO text
federalregister.gov/presidential-d…
And @PhRMA said no #drugprices meetings it's aware of this week, despite Trump's claim
Oh, and that health care plan Trump has promised since 2016 - four years ago - still no sight of it yet, either.
So Americans with #PreExistingConditions will just have to keep relying on #Obamacare / #ACA, the law that granted them those protections.
So Americans with #PreExistingConditions will just have to keep relying on #Obamacare / #ACA, the law that granted them those protections.
The White House on that health care plan & EO copying #Obamacare's #PreExistingConditions protections due today: 🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗
Reminder: Trump has promised a health care / #Obamacare replacement plan since 2016.
That was four years ago and he's still not revealed it.
Four years ago ... and still nothing.
🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗
That was four years ago and he's still not revealed it.
Four years ago ... and still nothing.
🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗🦗
Remember "favored nations" #drugpricing EO Trump was threatening #pharma #biotech with? He said he would put it into effect Aug. 25. Still no sign of it.
EOs have limited authority, can be difficult to enforce, take months/years to implement & can easily be challenged in court.
EOs have limited authority, can be difficult to enforce, take months/years to implement & can easily be challenged in court.
.@SecAzar on all the morning network shows making the same false claim that "We have & always have had the capacity to test anybody who's suspected of novel coronavirus."
And @GStephanopoulos doesn't challenge him on that.
#COVID19 #coronavirus
And @GStephanopoulos doesn't challenge him on that.
#COVID19 #coronavirus
'It's Just Everywhere Already': How Delays in Testing Set Back the U.S. Coronavirus Response
nytimes.com/2020/03/10/us/… #coronavirus #COVID19 @nytimes
How the Biogen leadership conference in Boston spread the coronavirus bostonglobe.com/2020/03/11/nat… @BostonGlobe
#COVID19 #coronavirus
nytimes.com/2020/03/10/us/… #coronavirus #COVID19 @nytimes
How the Biogen leadership conference in Boston spread the coronavirus bostonglobe.com/2020/03/11/nat… @BostonGlobe
#COVID19 #coronavirus
Today, a number of #COVID19 hearings on Capitol Hill, including @OversightDems w/ #NIH/ #NIAID Fauci, @CDCDirector @PHEgov Kadlec @DeptofDefense Rauch & @USGAO Currie oversight.house.gov/legislation/he…
#coronavirus #CDC
#coronavirus #CDC
#SriAgenda in abt 1h | #Feb27 5:30pm CET
#webinar
"@ICCRonline's 2020 Proxy Resolutions and Voting Guide Overview
register.gotowebinar.com/register/36317…
#proxyvoting #engagement #sustainablefinance #responsibleinvestment #sri #esg #shareholderactivism
#webinar
"@ICCRonline's 2020 Proxy Resolutions and Voting Guide Overview
register.gotowebinar.com/register/36317…
#proxyvoting #engagement #sustainablefinance #responsibleinvestment #sri #esg #shareholderactivism
@ICCRonline #SriAgenda just started 🔘 #webinar
"@ICCRonline's 2020 Proxy Resolutions and Voting Guide Overview
#proxyvoting #engagement #sustainablefinance #responsibleinvestment #sri #esg #shareholderactivism
"@ICCRonline's 2020 Proxy Resolutions and Voting Guide Overview
#proxyvoting #engagement #sustainablefinance #responsibleinvestment #sri #esg #shareholderactivism
@ICCRonline #HumanRights the emerging key trend this year in resolutions filed by @ICCRonline's members
#webinar
#BizHumanRights #BizHR #HRDD @SusanaMcDermott @dschilling44 @SeamusPFinn @PalomaMQuick @nminow @sara__blackwell @InvestForRights
#webinar
#BizHumanRights #BizHR #HRDD @SusanaMcDermott @dschilling44 @SeamusPFinn @PalomaMQuick @nminow @sara__blackwell @InvestForRights
Daniel Best, who worked for HHS, and helped lead the effor to lower prescription drug prices, was found dead around an apt complex garage. He died of “multiple blunt force injuries” but it was ruled a suicide. WTF?!?!
#DrugPricing
cleveland.com/metro/index.ss…
#DrugPricing
cleveland.com/metro/index.ss…
So, I looked up "suicide by multiple blunt force injuries" & came upon this medical article of an example. It's rare.
This guy (in link) had head injury, cuts, & abrasions all over his body,but also paranoid schizophrenic w/ previous suicide attempt.
ncbi.nlm.nih.gov/pubmed/12464812
This guy (in link) had head injury, cuts, & abrasions all over his body,but also paranoid schizophrenic w/ previous suicide attempt.
ncbi.nlm.nih.gov/pubmed/12464812
There's another brief example in here, and that person also had a history of schizophrenia.
ncbi.nlm.nih.gov/pubmed/23910842
ncbi.nlm.nih.gov/pubmed/23910842
