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Okay, so there has been a lot of news circulating about N440K variant being or not being the cause of second wave based on a study from our lab...I will just try to clarify the findings which have been discussed and how the findings were interpreted: a thread
#N440K #LongCovid
#N440K #LongCovid
So a few days back we published a preprint from our lab that N440K variant (also known as B.1.36) has more infectious fitness than its parent lineage A2a ( also known as D614G mutant or B.1.1.8) and an unrelated A3i variant (aka B.6)
We have also suggested that based on the sequence information on @GISAID till April 24th 2021, the proportion of N440K variants are increasing, clustering in some regions more than the others.
We need more studies on the double mutant strain found in India. Experts across the world have been asking for India to do more testing, research so we can know how infectious it is and vaccine impact.
Now it has been found in 10 countries. #covid #doublemutant
Now it has been found in 10 countries. #covid #doublemutant
We knew about the double mutant strain since last year, only announced earlier this year. If we studied it more extensively, we could have anticipated the second wave better #COVIDSecondWaveInIndia #DoubleMutant
A double mutant case was discovered in California a few weeks ago, then many cases in England and its now spread to 10 countries #DoubleMutant #COVID19India
Qu’est-ce que le variant indien "double mutant" B.1.617. ?
Un variant du #SARS_CoV_2 originaire d’Inde, décelé dès le 7/12/2020, qui pourrait être responsable d’une récente flambée des cas de 55% dans l’état du Maharashtra, après des mois de baisse. #COVID19 #DoubleMutant #B1617
Un variant du #SARS_CoV_2 originaire d’Inde, décelé dès le 7/12/2020, qui pourrait être responsable d’une récente flambée des cas de 55% dans l’état du Maharashtra, après des mois de baisse. #COVID19 #DoubleMutant #B1617
C'est aussi un sujet d'inquiétude pour les scientifiques et l'état Indien, avec notamment 15-20% des PCR effectuées dans la province de Maharashtra, où circulent déjà le B.1.1.7 UK, le B.1.351 sud africain et le N440K, un ptit nouveau aussi #COVID19 #DoubleMutant #B1617
70% des séquences génomiques présentant les mutations B.1.617, et soumises à la base de données mondiale GISAID (Global Initiative on Sharing Avian Influenza Data) proviennent d'Inde.
Puis du Royaume-Uni (23%), Singapour (2%) et de l'Australie (1%) #COVID19 #DoubleMutant #B1617
Puis du Royaume-Uni (23%), Singapour (2%) et de l'Australie (1%) #COVID19 #DoubleMutant #B1617
Since India announced the ‘E484Q & L452R’ #DoubleMutant , I was curious about the emergence of the ‘E484Q and L452R’ mutations. When I analyzed all publicly available #SARSCoV2 sequences, the first ever case was reported in Maharashtra, India in a sample collected on 12/5/2020.
In India, the Double Mutants are primarily found in Lineage B.1; USA- B.1.427 and B.1.429; Sweden-L.3. Outside of India only 46 sequences of double mutant were found, UK-22, USA-12 (mostly California), Sweden-5, Canada -3, 1 in Singapore, Germany, Australia and New Zealand each.
The E484Q mutation was first seen in a sample collected on 03/09/2020 in Midtjylland, Denmark; 03/20/2020 in San Diego, US; 03/22/2020 in Maharashtra, India; 5/20/2020 Wales, UK. The mutation is seen mostly in B.1 lineages including B.1.1.7 and mostly in India, USA and UK.
