Discover and read the best of Twitter Threads about #bloodcancer
Most recents (9)
🧵🧵
1/18
We at HCC are so proud of our team and participating centers. 6 abstracts of our collective work have been accepted for #ASH22. If you wish to be a part of this movement either as an individual or as a participating institution, do visit us at hemecancer.org/membership.php
1/18
We at HCC are so proud of our team and participating centers. 6 abstracts of our collective work have been accepted for #ASH22. If you wish to be a part of this movement either as an individual or as a participating institution, do visit us at hemecancer.org/membership.php
@chepsyphilip @pb10_bmt @udaypkulkarni @NancyArthurPhD @DrArunCMC @dranupjdevasia @DrNikitaMehra @faheema_hasan @madhavi_maddali @jayastuMD @MJosephJohn1 @dbhurani @lingarajnayak @Prasshmehta @hkJain_kmc @b_poonkuzhali @nvpatkar @rayaz_hemat @drmanuprasad
2/18
#2976 Prognostic Factors and Outcomes of Adolescent and Adult Burkitt Lymphoma and Leukemia from a Low-Middle Income Country: An Experience from Hematology Cancer Consortium
ash.confex.com/ash/2022/webpr…
#2976 Prognostic Factors and Outcomes of Adolescent and Adult Burkitt Lymphoma and Leukemia from a Low-Middle Income Country: An Experience from Hematology Cancer Consortium
ash.confex.com/ash/2022/webpr…
It's #MyelomaAwarenessMonth & we're going to share some facts about #myeloma
First things first... what is #myeloma?
Myeloma is a type of #bloodcancer that affects plasma cells in the bone marrow.
Keep reading to find out more & help us educate others by giving us a RT
1/6
First things first... what is #myeloma?
Myeloma is a type of #bloodcancer that affects plasma cells in the bone marrow.
Keep reading to find out more & help us educate others by giving us a RT
1/6
Did you know...
That the acronym 'CRAB' is used to remember the common symptoms of #myeloma?
Each letter of CRAB stands for something that causes the symptoms of myeloma.
Find out what they are 👇
2/6
That the acronym 'CRAB' is used to remember the common symptoms of #myeloma?
Each letter of CRAB stands for something that causes the symptoms of myeloma.
Find out what they are 👇
2/6
'C' stands for too much calcium in the blood, and it can cause people to:
🤮 Feel sick
❌Have a low appetite
🧻 Have difficulty pooing
🚽 Need to wee more often
🥤 Feel thirsty
🥱Have a lack of energy
😵💫Feel confused
#MyelomaAwarenessMonth 3/6
🤮 Feel sick
❌Have a low appetite
🧻 Have difficulty pooing
🚽 Need to wee more often
🥤 Feel thirsty
🥱Have a lack of energy
😵💫Feel confused
#MyelomaAwarenessMonth 3/6
#tweetorial 🧵
🚩Metabolism and Acute Myeloid Leukemia
(1/23)
➡️📈🔎Increased attention over the last decade on the metabolic perturbations in AML
➡️Potential therapeutic implications – with ‘druggable’ targets
🚩Metabolism and Acute Myeloid Leukemia
(1/23)
➡️📈🔎Increased attention over the last decade on the metabolic perturbations in AML
➡️Potential therapeutic implications – with ‘druggable’ targets
(2/23)
➡️🗒️📌Summary of recent concepts
🔊IT IS ALL HAPPENING IN THE MITOCHONDRIA
👉📈🏹Increase potential of targeting the mitochondria
👉🦀Anti-cancer agents specifically targeting cancer cell mitochondria are referred to as 'mitocans'
➡️🗒️📌Summary of recent concepts
🔊IT IS ALL HAPPENING IN THE MITOCHONDRIA
👉📈🏹Increase potential of targeting the mitochondria
👉🦀Anti-cancer agents specifically targeting cancer cell mitochondria are referred to as 'mitocans'
(3/23)
➡️Metabolic adaptions of AML cells
AML is a 🦀cancer derived from the myeloid lineage of blood🩸cells, characterized by overproduction of malignant cells.
➡️Metabolic adaptions of AML cells
AML is a 🦀cancer derived from the myeloid lineage of blood🩸cells, characterized by overproduction of malignant cells.
#tweetorial 🧵
➡️Ph-like ALL / BCR-ABL1-like ALL
👉A provisional entity in the 2016 World Health Organization classification of acute leukemia 🩸🩸
👉Gene expression 🧬signature similar to Ph-positive ALL but lacks the BCR-ABL1 translocation
@NancyArthurPhD
➡️Ph-like ALL / BCR-ABL1-like ALL
👉A provisional entity in the 2016 World Health Organization classification of acute leukemia 🩸🩸
👉Gene expression 🧬signature similar to Ph-positive ALL but lacks the BCR-ABL1 translocation
@NancyArthurPhD
➡️Originally defined by gene expression 🧬profiling in 2009 by 2 groups
👉Children's Oncology Group (COG) and St. Jude Children's Research Hospital (referred to as Ph-like ALL) 👉Dutch Childhood Oncology Group (referred to as BCR-ABL1-like ALL) – DCOG/COALL
👉Children's Oncology Group (COG) and St. Jude Children's Research Hospital (referred to as Ph-like ALL) 👉Dutch Childhood Oncology Group (referred to as BCR-ABL1-like ALL) – DCOG/COALL
👉The differences in the approaches are outlined in the figure; more on the gene expression 🧬 signatures and diagnostic conundrums later!
"VEXAS SYNDROME", a multidisciplinary team of researchers @genome_gov have identified this new disorder:
(1/8)
➡️Monogenic adult-onset autoinflammatory disease affecting males ♂️👨👦
(1/8)
➡️Monogenic adult-onset autoinflammatory disease affecting males ♂️👨👦
(2/8)
➡️Caused by a mutation in the UBA1 gene 🧬 that encodes major E1 enzyme that initiates ubiquitylation
➡️Suggests postzygotic somatic mutation may be a more frequent cause of human disease👨
➡️Patients develop inflammatory symptoms🔥and hematological abnormalities🩸👇
➡️Caused by a mutation in the UBA1 gene 🧬 that encodes major E1 enzyme that initiates ubiquitylation
➡️Suggests postzygotic somatic mutation may be a more frequent cause of human disease👨
➡️Patients develop inflammatory symptoms🔥and hematological abnormalities🩸👇
(3/8)
🔥🔥INFLAMMATORY SYMPTOMS
👉Fatigue 😫
👉Recurrent fever 🤒🌡️
👉Lung infiltrates 🫁
👉Skin lesions🔴
👉Ear chondritis👂
👉and vasculitis
🔥🔥INFLAMMATORY SYMPTOMS
👉Fatigue 😫
👉Recurrent fever 🤒🌡️
👉Lung infiltrates 🫁
👉Skin lesions🔴
👉Ear chondritis👂
👉and vasculitis
Vandaag wordt voor de vijfde keer de internationale ‘AML World Awareness Day’ gehouden om aandacht te vragen voor acute myeloïde leukemie (#AML), een zeldzame vorm van bloedkanker. #NKRdata #leusm #leukemia #bloodcancer #KnowAML @IKNL @KNOW_AML @HematonNL (1/16)
AML treft momenteel ruim 750 patiënten per jaar in Nederland (zie figuur). Op basis van de internationale
RARECARE-definitie voor zeldzame kanker is AML een zeldzame kankersoort #NKRdata #leusm #bloodcancer #KnowAML @IKNL @KNOW_AML (2/16)
RARECARE-definitie voor zeldzame kanker is AML een zeldzame kankersoort #NKRdata #leusm #bloodcancer #KnowAML @IKNL @KNOW_AML (2/16)
Volgens de RARECARE-definitie is een kankersoort zeldzaam als het minder dan zes nieuwe gevallen per 100.000 personen per jaar treft. Voor Nederland betekent dit dat een kankersoort zeldzaam is als er minder dan 1.021 nieuwe diagnoses per jaar zijn. (3/16)
👧 Supporting your child's mental health 👦
(A thread...)
(A thread...)
👨👩👦 Our Support Services Team have been hearing from lots of people who's children are experiencing anxiety around going to school, and are worried about the risk of bringing the virus home with them and infecting a parent who has #bloodcancer. 1/
🏥 This is a difficult situation for both children and parents. Sometimes, your treatment team might have access to psychological support for your children or teenagers, or an option to get support as family – it's worth asking. 2/
1/ "How long have I had it for?"
Our patients with #bloodcancer have always wanted to know. We set out to answer it. We studied patients with MPN #mpnsm and found quite unexpected results. Excited to share our preprint biorxiv.org/content/10.110…
Our patients with #bloodcancer have always wanted to know. We set out to answer it. We studied patients with MPN #mpnsm and found quite unexpected results. Excited to share our preprint biorxiv.org/content/10.110…
2/ We took single blood cells from patients with MPN and grew each cell into a colony. We then sequenced each colony's whole genome (>950 whole genomes).
3/ We used DNA mutations to trace the ancestral relationships between colonies - building a "family tree" of blood production for each patient. We could then time the cancer driving genetic events and trace how the mutant clones expanded over the patient’s life.
📆 Today is #CancerSurvivorsDay 📆
Here at Blood Cancer UK, we want to use today to raise awareness of what #survival means to those who live with slow-growing (chronic) #bloodcancer, and share some of their stories.
Read the rest of our thread to find out more.... 👇
Here at Blood Cancer UK, we want to use today to raise awareness of what #survival means to those who live with slow-growing (chronic) #bloodcancer, and share some of their stories.
Read the rest of our thread to find out more.... 👇
👨👩👦As many of our community will know, surviving blood cancer can be a very different experience to overcoming some other types of cancer.
🔎For those with chronic blood cancer, 'survival' means learning to adapt and finding new ways of living to accommodate ongoing symptoms.
🔎For those with chronic blood cancer, 'survival' means learning to adapt and finding new ways of living to accommodate ongoing symptoms.
😴 This is the case for Erica, who has chronic lymphocytic leukaemia (CLL) and experiences extreme tiredness (fatigue) as a result.
