Discover and read the best of Twitter Threads about #bivalent
Most recents (9)
#COVID19 #VariantDashboard - #UnitedStates
TOP lineages (#15DAYTRENDS):
69.3% XBB.1.5
6.8% XBB.1.16
4.8% XBB.1.9.1
1.4% XBB.1.5.15
1.4% XBB.1.5.1
1.2% XBB.2.3
1.1% XBB.1.9.2
1.0% XBB.1.5.17
#SARSCoV2 Tracker: tinyurl.com/mryj4uu7 Updated: 04/18/23
1/n
TOP lineages (#15DAYTRENDS):
69.3% XBB.1.5
6.8% XBB.1.16
4.8% XBB.1.9.1
1.4% XBB.1.5.15
1.4% XBB.1.5.1
1.2% XBB.2.3
1.1% XBB.1.9.2
1.0% XBB.1.5.17
#SARSCoV2 Tracker: tinyurl.com/mryj4uu7 Updated: 04/18/23
1/n
Use "Airport Surveillance" (AS) pull-down menu to easily track variant proportions Nationally or by State with or without AS sequences
Top lineages (#15DayTrends w/o AS seqs):
XBB.1.5 (73.3%),
XBB.1.9.1 (4.8%),
XBB.1.16 (3.0%),
XBB.1.5.15 (1.7%),
XBB.1.5.1 (1.4%)
2/n
Top lineages (#15DayTrends w/o AS seqs):
XBB.1.5 (73.3%),
XBB.1.9.1 (4.8%),
XBB.1.16 (3.0%),
XBB.1.5.15 (1.7%),
XBB.1.5.1 (1.4%)
2/n
Sequence count by US States
#NewYork, #California, #Florida, #Arizona, #NorthCarolina and #NewJersey have submitted a big share of sequences with specimen collection dates on or after 04/03/2023
XBB.1.5 is still at the top spot; followed by XBB.1.9.1, XBB.1.16, XBB.1.5.15
3/n
#NewYork, #California, #Florida, #Arizona, #NorthCarolina and #NewJersey have submitted a big share of sequences with specimen collection dates on or after 04/03/2023
XBB.1.5 is still at the top spot; followed by XBB.1.9.1, XBB.1.16, XBB.1.5.15
3/n
Updated #Booster (#Bivalent) uptake in #USA
Who's boosted so far
~16% of total population (54.6 Million)
~42% of population 65 years or older (~23 Million)
@CDCgov recommends everyone stay up to date with #COVID19 vaccines for their age group
cdc.gov/coronavirus/20…
Who's boosted so far
~16% of total population (54.6 Million)
~42% of population 65 years or older (~23 Million)
@CDCgov recommends everyone stay up to date with #COVID19 vaccines for their age group
cdc.gov/coronavirus/20…
Percent of the Population 65 Years of Older with an Updated (Bivalent) Booster Dose (Source: @CDCgov)
Percent of the Population 18 Years of Age and Older with an Updated (Bivalent) Booster Dose (Source: @CDCgov)
#NZ our MOH has an April Fools Day surprise for you
The new bivalent #covidvaccine will be rolled out as a booster to everyone (who wants it) age 30 plus REGARDLESS OF HOW MANY PREVIOUS VACCINE DOSES YOU HAVE HAD
The new bivalent #covidvaccine will be rolled out as a booster to everyone (who wants it) age 30 plus REGARDLESS OF HOW MANY PREVIOUS VACCINE DOSES YOU HAVE HAD
That means the elderly who have just had dose 5 are encouraged into dose 6, as long as it's six months since their last dose. This time they get a special "two for one deal" - bivalent booster AND the flu jab at the same time
Minister of Health Verrall says "one of my priorities as Minister is to be better prepared this winter, this rollout is an important part of this"
1/🧵COVID Re-Infection⚠️
Let’s learn
🔹Re-infection is a worry
🔹⬆️ plasma Nucleocapsid (N) Antigen levels predict outcomes
🔹If you get COVID, the best predictor of ⬇️ N-Ag levels (ie, viral replication) is having Spike Ab
🔹You get S-Ab by Vaxx
Read on
bit.ly/3Ha8q2g
Let’s learn
🔹Re-infection is a worry
🔹⬆️ plasma Nucleocapsid (N) Antigen levels predict outcomes
🔹If you get COVID, the best predictor of ⬇️ N-Ag levels (ie, viral replication) is having Spike Ab
🔹You get S-Ab by Vaxx
Read on
bit.ly/3Ha8q2g
2/ These data (N=2540) come from ACTIV-3 study of adults hospitalized for COVID in 114 centers in 10 countries Aug 2020-Nov 2021
I’m going back over this because there are so many people walking around without adequate protection due to waning immunity over time.
I’m going back over this because there are so many people walking around without adequate protection due to waning immunity over time.
3/ N-Antigen levels (which we don’t measure in practice) are a measure of viral replication & predict outcomes
Plasma N-Antigen levels are highly associated w Antibody (Ab) status
⬆️ anti-S (spike) Antibodies at time of COVID infection predicts ⬇️ virus & safety
How so?
Plasma N-Antigen levels are highly associated w Antibody (Ab) status
⬆️ anti-S (spike) Antibodies at time of COVID infection predicts ⬇️ virus & safety
How so?
Our new preprint on the durability of #bivalent #mRNA vaccines against #XBB.1.5 is out now! We looked at both humoral & cellular immune responses up to 3 months post boost! @BarouchLab @airisyc @ocpowers5599 @mrowe1625
TL;DR: PLEASE GET A BOOSTER!
biorxiv.org/content/10.110…
TL;DR: PLEASE GET A BOOSTER!
biorxiv.org/content/10.110…
We first looked at the nAbs induced by bivalent mRNA vaccines against BQ.1.1, XBB.1, and XBB.1.5 at baseline, 3-weeks-post boost and 3 months post boost. nAb levels peaked at week 3 post-boost, but waned over a period of time.
We also looked at CD4 and CD8 T cell responses post boost, and found at least a 2-fold increment in CD8T cells specific to BQ.1.1 and XBB.1.5, but not as much for WA_1! What does this mean for T cells? Do they have a more pronounced role than previously understood?
⚠️NEXT BIG ONE—CDC has royally screwed up—unreleased data shows #XBB15, a super variant, surged to 40% US (CDC unreported for weeks!) & now causing hospitalization surges in NY/NE.➡️XBB15–a new recombinant strain—is both more immune evasive & better at infecting than #BQ & XBB.🧵
2) Multiple models show #XBB15 is much worse in transmission R value and infection rate than previous variants — faster by LEAPS and BOUNDS. @JPWeiland did some the earliest models on #XBB15 watching data in NY. it has only grown worse nationwide.
3) in fact, when @JPWeiland first modeled #XBB15 before Xmas, the data shows XBB15 was 108% faster than the previously king #BQ1 variant. But with more data, XBB15 has further accelerated to now being 120% faster!
⚠️BREAKING—CDC now confirms my scoop that super evasive #BQ1 & #BQ11 variants (Typhon & Cerberus) have meteorically surged from *unlisted* 3 weeks ago, to 11% 2 weeks ago—to ⬆️now suddenly 27% today! This is a bad 10-day doubling time! 🇬🇧’s #BQ ~30% too🧵
covid.cdc.gov/covid-data-tra…
covid.cdc.gov/covid-data-tra…
Coming out as #bivalent
And now I am initiating the I Am Baby Protocol (retiring to bed with a bottle of Sprite) to maximize the chance that my body is done dealing with this in time for me to get groceries tomorrow.
In a new study, the researchers develop a panel of mRNA-LNP-based vaccines using the RBD of #Omicron & #Delta, which are dominant in the current wave of COVID-19. 1/
In addition to the Omicron- & Delta-specific vaccines, the panel also includes a “#Hybrid” vaccine that uses the RBD containing all 16 point-mutations shown in Omicron & Delta RBD, as well as a #bivalent vaccine composed of both Omicron and Delta RBD-LNP in half dose. 2/
Interestingly, both Omicron-specific & Hybrid RBD-LNP elicited extremely high titer of NAbs against Omicron itself, but few to none NAbs against other SARS-CoV-2 variants. 3/
