Discover and read the best of Twitter Threads about #baricitinib
Most recents (7)
Abro 🧵para hacer un recuento de lo que el #Año2022 nos dejó:
1. La aprobación por la @US_FDA en Noviembre del Tzield (#Teplizumab), un anticuerpo monoclonal anti-CD3 que retrasa la aparición de la #diabetes tipo 1.
1. La aprobación por la @US_FDA en Noviembre del Tzield (#Teplizumab), un anticuerpo monoclonal anti-CD3 que retrasa la aparición de la #diabetes tipo 1.
2. La publicación en @ScienceMagazine de la fase 1 del ensayo clínico con la #vacuna eOD-GT8-AS01B para prevenir el #VIH, que indujo la sintesis de #anticuerpos neutralizantes vs el virus, en el 97% de los que fueron vacunados.
🧵1/ Here’s your “Big Picture” of COVID & Long COVID for 2022
See my new Figure👇 summarizing #COVID19 Management & Outcomes
Two years in & we have splendid choices.
Stay in peaceful waters of prevention (green) or risk treacherous cliffs of #LongCOVID & Death (red & black)…
See my new Figure👇 summarizing #COVID19 Management & Outcomes
Two years in & we have splendid choices.
Stay in peaceful waters of prevention (green) or risk treacherous cliffs of #LongCOVID & Death (red & black)…
2/ Knowledge is Power, and our knowledge has grown dramatically.
Let’s take a look at where we were just 2 years ago - even though it seems like 20 yrs ago.
April 2020: our approach & understanding of COVID looked like this👇.
We didn’t even know about #LongCOVID yet 🤯
Let’s take a look at where we were just 2 years ago - even though it seems like 20 yrs ago.
April 2020: our approach & understanding of COVID looked like this👇.
We didn’t even know about #LongCOVID yet 🤯
3/ Remember, with #LongCOVID, your brain & heart are at stake.
@JohnsHopkinsSPH reports on emerging data: “COVID doesn’t discriminate when it comes to heart problems.”
Anyone affected may develop clots, arrhythmias & strokes >1 yr later.
Link &🧵below
bit.ly/3KzYcbp
@JohnsHopkinsSPH reports on emerging data: “COVID doesn’t discriminate when it comes to heart problems.”
Anyone affected may develop clots, arrhythmias & strokes >1 yr later.
Link &🧵below
bit.ly/3KzYcbp
Updated WHO severe COVID treatment guidelines bit.ly/3rhGgKW
Recommended
🟢Steroid (#Dexamethasone)
🟢IL6 blocker (#Toci) or 🟢JAKi (#Baricitinib)
🟠±mAb in seronegative people
NOT recommended
🔴#Hydroxychloroquine
🔴#ivermectin
🔴#remdesivir
Lots to discuss, a🧵
1/
Recommended
🟢Steroid (#Dexamethasone)
🟢IL6 blocker (#Toci) or 🟢JAKi (#Baricitinib)
🟠±mAb in seronegative people
NOT recommended
🔴#Hydroxychloroquine
🔴#ivermectin
🔴#remdesivir
Lots to discuss, a🧵
1/
Remdesivir (RDV) is in the “We suggest no remdesivir” category.
At some level, this isn’t too surprising & is old news.
Despite initial hype, RDV never moved the needle much on patient centered outcomes (risk of mortality or requiring IMV) & many of us had stopped using it.
2/
At some level, this isn’t too surprising & is old news.
Despite initial hype, RDV never moved the needle much on patient centered outcomes (risk of mortality or requiring IMV) & many of us had stopped using it.
2/
In #ACTT1 RDV did improve outcomes on an ordinal scale, but the effect was modest. It shortened time to clinical improvement but not hospital LOS (patients stayed in the hospital longer to receive it).
RDV did NOT improve mortality or risk of IMV.
ncbi.nlm.nih.gov/pubmed/32445440
3/
RDV did NOT improve mortality or risk of IMV.
ncbi.nlm.nih.gov/pubmed/32445440
3/
IMPORTANT THREAD on #COVIDTreatments - What Works & What Does not. Will be an ongoing threat.
Start with Dr Zarir Udwadia of Mumbai.
Start with Dr Zarir Udwadia of Mumbai.
Link to Dr Udwadia's Video
1st Point: 90000+ Medical papers on Covid. UNFORTUNATELY, big divergence in Observational Studies impact and Real World impact of a rigorous RCT
1st Point: 90000+ Medical papers on Covid. UNFORTUNATELY, big divergence in Observational Studies impact and Real World impact of a rigorous RCT
RCT is Randomized controlled trial.
A Good website is Covid19Primer.com
2) What Works ?
(A) Steroids are essential. #DEXAMETHASONE 6mg/day for Critically ill Covid Patients. Reduces Death by 33/20% for Patients on Ventilators & Oxygen.
A Good website is Covid19Primer.com
2) What Works ?
(A) Steroids are essential. #DEXAMETHASONE 6mg/day for Critically ill Covid Patients. Reduces Death by 33/20% for Patients on Ventilators & Oxygen.
It took a while to digest the details of over 600 pages, but here is my review and comparative analysis of the #ACTT2 trial that compared #baricitinib vs. #placebo among patients receiving #remdesivir for #COVID19!
Some very interesting insights, I think!
Sit briefly and enjoy!
Some very interesting insights, I think!
Sit briefly and enjoy!
Will be mainly comparing #ACTT2 to #ACTT1, but also will get some insights and questions that come up when comparing #ACTT2 to the #dexamethasone #RecoveryTrial
The idea of using #baricitinib (aka Bari) for #COVID19 is in this commentary in .@TheLancet from Feb. when Peter Richardson & Co working .@benevolent_ai .@ucl searched drugs and noted that #bari could block inflammation & viral endocytosis.
link: thelancet.com/journals/lance…
link: thelancet.com/journals/lance…
Nice explanation about vaccines efficacy, development and trials by @mlipsitch
Must read 👌
@Virusemergentes @Luis_Corral_Gud
@ligero999 @MariadelMarTom
science.sciencemag.org/content/early/…
Must read 👌
@Virusemergentes @Luis_Corral_Gud
@ligero999 @MariadelMarTom
science.sciencemag.org/content/early/…
No quiero dejar de traer al hilo este ensayo con plasma de convaleciente que me llega a través de @gorka_orive
El ensayo tiene algunas limitaciones pero la evidencia que aporta no debería soslayarse. No son buenas noticias
bmj.com/content/371/bm…
El ensayo tiene algunas limitaciones pero la evidencia que aporta no debería soslayarse. No son buenas noticias
bmj.com/content/371/bm…
Current list of widely available therapeutics for #Covid_19
Added Bromhexine, Nitazoxanide, & inhaled interferon
h/t @__ice9
cc @drakchaurasia @drkrvcvijay @DrJoyeeta @drprashant86jmd
Added Bromhexine, Nitazoxanide, & inhaled interferon
h/t @__ice9
cc @drakchaurasia @drkrvcvijay @DrJoyeeta @drprashant86jmd
Commonly available drugs:
(minimum side effects)
Bromhexine+Omeprazole
Famotidine
Loperamide
VitaminsABCD+Zinc
Quercetin+Bromelain
Colchicine trial ongoing
Combine with 1 among these prescription drugs:
Doxycycline/Indomethacin/Dipyridamole/Ciclesonide
(minimum side effects)
Bromhexine+Omeprazole
Famotidine
Loperamide
VitaminsABCD+Zinc
Quercetin+Bromelain
Colchicine trial ongoing
Combine with 1 among these prescription drugs:
Doxycycline/Indomethacin/Dipyridamole/Ciclesonide
Loperamide is the odd one out here.
I put it because it is non-prescription & there is A research paper which suggests that it could disrupt the Cholesterol Synthesis Pathway
Prescription alternatives would be Fluvostatin + Losarton
I put it because it is non-prescription & there is A research paper which suggests that it could disrupt the Cholesterol Synthesis Pathway
Prescription alternatives would be Fluvostatin + Losarton
