Discover and read the best of Twitter Threads about #XD
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Nuove varianti e tornano le preoccupazioni, questo thread non vuole essere un riassunto delle varianti attuali ma una GUIDA per districarsi nelle informazioni e per pesarle:
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#Covid_19 #Variant #OmicronXE #Omicron #XE #XD
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#Covid_19 #Variant #OmicronXE #Omicron #XE #XD
1) questo virus è il più studiato della storia, abbiamo un livello di dettaglio mai visto prima. Moltissime delle informazioni sono estremamente tecniche e difficili da capire e contestualizzare. I migliori scienziati al mondo sono al lavoro sulle varianti --> don't panic
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2) i virus naturalmente mutano e lo fanno in continuazione: è nella loro 'natura'. Non dobbiamo stupirci o preoccuparci per una nuova variante, fin quando circolerà, muterà.
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Characterisation of a new recombinant, #XD (a Delta-Omicron recombinant)
➡️ The XD is a chimeric SARS2 virus having recombination of Delta AY.4 & Omicron BA.1.
➡️ The XD spike carries a larger fraction of the signature changes of BA.1, including the entirety of the RBD
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➡️ The XD is a chimeric SARS2 virus having recombination of Delta AY.4 & Omicron BA.1.
➡️ The XD spike carries a larger fraction of the signature changes of BA.1, including the entirety of the RBD
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There are two breakpoints, one at the beginning of spike & one within ORF 3a
➡️ Immune escape:
-With pseudovirus, only a small reduction in NAb titers ag #Delta compared to WT
-In contrast, both XD & BA.1 were barely neutralized by sera sampled 1 or 6 mo after 2 doses
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➡️ Immune escape:
-With pseudovirus, only a small reduction in NAb titers ag #Delta compared to WT
-In contrast, both XD & BA.1 were barely neutralized by sera sampled 1 or 6 mo after 2 doses
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-The titers were all much higher 1 month after a 3rd immunization, although they displayed an 8-fold to 10-fold reduction in neutralization efficacy against both BA.1 and XD compared to the WT virus.
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A lot of noise is being generated in the media regarding recombinants, i.e. Deltacron. The later is a misnomer & shouldn’t be used.
@PeacockFlu took pain to discuss these issues in details.
What are the new recombinants, i.e. XD, XE & XF? Which could be the most concerning?
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@PeacockFlu took pain to discuss these issues in details.
What are the new recombinants, i.e. XD, XE & XF? Which could be the most concerning?
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#XD is French Delta x BA.1. It contains the Spike protein of BA.1 and the rest of the genome from Delta.
#XE is a large UK BA.1 x BA.2. It has the Spike & structural proteins from BA.2 but the 5' part of its genome from BA.1. 2/
#XE is a large UK BA.1 x BA.2. It has the Spike & structural proteins from BA.2 but the 5' part of its genome from BA.1. 2/
#XF is a UK Delta x BA.1. It has the Spike & structural proteins from BA.1 but the 5' part of its genome from Delta. 3/
Wireframe Kits need to be more Discoverable & Searchable. Each Frame of #WireframeKit must be listed separately. Right now a big #Wireframe kit with multiple number of frames are clubbed in a single file make it less discoverable. @Adobe @files_design @iconfinder #UI #XD #Sketch
We need faster way to slice frames from wireframe kit and a design repository to arrange them visually. It must be easily searched and pull to scene from XD interface. #adobexd
# Exploring Tweetbonds
Continuing speculations on building an informal economy of sorts using standard Twitter functions only.
See the below for the initial draft, though Ive evolved the idea since then
Continuing speculations on building an informal economy of sorts using standard Twitter functions only.
See the below for the initial draft, though Ive evolved the idea since then
If someone deletes a Reply to you, there is no record that such a Reply ever existed(*). One could of course make a screenshot (aka screencap) but screenshots can be faked to say whatever you want.
(*) Actually, twitter may retain the Reply, I dunno.
(*) Actually, twitter may retain the Reply, I dunno.
Quote Tweets (QTs) are a different matter. A nested set of QTs, entered in reverse order & punctuated in specific ways, can be made 'secure' in the sense that
1) You can't add to the initial tweet, and
2) You can't add to the final tweet w/o some break in a punctuation protocol.
1) You can't add to the initial tweet, and
2) You can't add to the final tweet w/o some break in a punctuation protocol.
