Discover and read the best of Twitter Threads about #VOCs
Most recents (13)
🚨New pre-print!🚨
biorxiv.org/content/10.110…
Viruses are very small things with very big effects. During the #SARSCoV2 pandemic, tiny changes in molecular biology had huge impacts on people’s lives. How could we communicate about this clearly?
🦠#scicomm #sciart🦠
(1/9)
biorxiv.org/content/10.110…
Viruses are very small things with very big effects. During the #SARSCoV2 pandemic, tiny changes in molecular biology had huge impacts on people’s lives. How could we communicate about this clearly?
🦠#scicomm #sciart🦠
(1/9)
In a new study with @CVRinfo @GSofASimVis and @COGUK_ME, @sarahiannucci1 explains how she used animations and interactive visualisations to help explain the threat of #SARSCoV2 variants of concern (#VOCs; 2/9)
There were, of course, plenty of data out there, collected by groups like @COGUK_ME. But these sites were (quite reasonably) aimed at expert audiences.
Could the details of new SARS-CoV-2 variants be explained in a way that was accessible for the public? (3/9)
Could the details of new SARS-CoV-2 variants be explained in a way that was accessible for the public? (3/9)
Wastewater contains a treasure trove of information for monitoring public health.
In our new paper, we solve several lab and computational bottlenecks to achieve timely, accurate, and cost-effective SARS-CoV-2 surveillance using wastewater sequencing. nature.com/articles/s4158…
In our new paper, we solve several lab and computational bottlenecks to achieve timely, accurate, and cost-effective SARS-CoV-2 surveillance using wastewater sequencing. nature.com/articles/s4158…
Our approach enabled early detection of emerging virus lineages (by as much as two weeks) and often detected lineages not seen clinically. Using a single sample, we profiled virus lineage dynamics from the scale of an entire city all the way to individual buildings.
This project truly took a village. It was a close @K_G_Andersen lab collaboration with @smruthi_karthik of @KnightLabNews, and so many contributors from @UCSanDiego @scrippsresearch @ScrippsHealth @radychildrens @sharphealthcare @SanDiegoCounty @CAPublicHealth @my_helix
So excited to finally share the latest from our group just published in @CellCellPress describing a next-generation trivalent COVID-19 vaccine that is designed to protect against all variants, and is delivered mucosally 1/n
This was a huge @McMasterU team effort, co-led with my incredibly talented colleagues, Dr. Zhou Xing and Dr. Brian Lichty. This vaccine is now in Phase I clinical trial, led by @inhaled_cov_vax 2/n
The real heroes behind this incredible story are the trainees who worked tirelessly to get this done on an unbelievably short timeline. Dr. Sam Afkhami from the Xing group and Mike D’Agostino from my group are co-first authors of the study
Preprint com alguns dados da neutralização de anticorpos de recuperados e vacinados contra a variante de interesse (VOI) #Mu
Devo me preocupar? O que os dados significam?
Vou abordar também outras variantes, como a #Delta neste fio
E aí, vai perder de ler? 🧐 Acompanha! 👇🧶
Devo me preocupar? O que os dados significam?
Vou abordar também outras variantes, como a #Delta neste fio
E aí, vai perder de ler? 🧐 Acompanha! 👇🧶
Hoje vi muitas análises comentando sobre o preprint abaixo, trazendo alguns dados importantes, mas com um tom alarmista, o que pode fazer com que a gente entenda de forma equivocada algumas coisas. Então, vamos entender juntos!
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Se tu quiser saber mais sobre a #Mu comentei sobre ela nesse fio:
Quais as contribuições da resposta humoral (ex.: anticorpos) e resposta celular induzida pela infecção e pela vacina (ex.: de RNA mensageiro) frente a infecção por SARS-CoV-2?
Belo artigo publicado pelo grupo da Dra. @VirusesImmunity , confira os dados abaixo 🧶👇
Belo artigo publicado pelo grupo da Dra. @VirusesImmunity , confira os dados abaixo 🧶👇
Antes de tudo, é importante lembrar alguns componentes celulares presentes na resposta imunológica, como os linfócitos T (CD4 e CD8), B e as células de memória, que explico nos próximos 3 tuítes desse fio:
Cada elemento da resposta imune é importante para a proteção, desde a 1ª infecção, até na proteção de longo prazo. Os anticorpos, p.ex., são importantes para evitar a infecção, e sua presença confere um risco menor de reinfecção nos 6 meses seguintes.
pubmed.ncbi.nlm.nih.gov/33369366/
pubmed.ncbi.nlm.nih.gov/33369366/
Muita gente ficou surpresa com as notícias referentes a C.1.2, uma variante possível aumento na transmissão e com algum escape imunológico anunciada pelo Inst. Nacional de Doenças Transmissíveis da 🇿🇦 e da Plataforma de Inov.e Seq. de Pesq. KwaZulu-Natal
Acompanha 🧶👇
Acompanha 🧶👇
RESUMO:
🔹Variante com características preocupantes, mas que não tem circulação global
🔹Nada nos diz que vacinas não abrangeriam ela
🔹Mais um indicativo de que o vírus está se adaptando
🔹A desigualdade de distr. de 💉 no 🌎 É UM PROBLEMÃO
🔹💉E 😷pelo amor de Deus
Detalhes👇
🔹Variante com características preocupantes, mas que não tem circulação global
🔹Nada nos diz que vacinas não abrangeriam ela
🔹Mais um indicativo de que o vírus está se adaptando
🔹A desigualdade de distr. de 💉 no 🌎 É UM PROBLEMÃO
🔹💉E 😷pelo amor de Deus
Detalhes👇
Não é segredo, nem novidade, que a permanência desse estado de transmissão elevado, que é construído por vários fatores, (baixa cobertura 💉, falta de adesão adequada a medidas como uso de 😷, p.ex), gera um risco de vermos novas variantes surgirem
Um brilhante fio de @sailorrooscout discutindo sobre células B de memória induzidas por vacina de RNA, que continuam a aumentar em frequência pelo menos (mas não somente) por 6 meses, MESMO com a queda de anticorpos circulantes!
Acompanhe 🧶👇
Acompanhe 🧶👇
Antes de tudo: @sailorrooscout com certeza é meu perfil favorito de fora do país para acompanhar a pandemia e as vacinas. Sigam esse perfil, é super tranquilo usar a ferramenta de tradução do twitter!
Thanks a lot for all your efforts @sailorrooscout ♥️
Thanks a lot for all your efforts @sailorrooscout ♥️
O estudo foi publicado ontem (23/08/21) na forma de preprint no @biorxivpreprint e pode ser acessado pelo link: biorxiv.org/content/10.110…
Ergänzend zum gestrigen #OktoberImAugust Thread heute noch ein paar weitere Einblicke in #Hospitalisierungen #Kinderdurchseuchung
TLR: #KeineEntkopplung:
Steigt Inzidenz, steigt #Belastung der Krankenhäuser - und der niedergelassenen sowieso.
Ausführlicher im Thread:➡️
1/x
TLR: #KeineEntkopplung:
Steigt Inzidenz, steigt #Belastung der Krankenhäuser - und der niedergelassenen sowieso.
Ausführlicher im Thread:➡️
1/x
2/
Betrachtet man die #Hospitalisierungsinzidenz-en für alle Altersgruppen über den Gesamtzeitraum, sieht erstmal alles #Tutti aus, weniger als KW44/20 bis 23/21.
Aber zu den Werten gehörten auch 90.000 Tote, das wollen wir ja auch nicht wiederholen.
Wie ist der Trend?
➡️
Betrachtet man die #Hospitalisierungsinzidenz-en für alle Altersgruppen über den Gesamtzeitraum, sieht erstmal alles #Tutti aus, weniger als KW44/20 bis 23/21.
Aber zu den Werten gehörten auch 90.000 Tote, das wollen wir ja auch nicht wiederholen.
Wie ist der Trend?
➡️
3/
Betrachtet man letzte 2 Monate, steigt nicht nur #Hospitalisierung bei #Kinderdurchseuchung, sondern auch bei 80+ sehr deutlich,
ebenfalls 60-79Jahre steigend, ähnliche Höhe wie #Hospitalisierungsinzidenz der 0-4Jährigen.
War das zu erwarten?➡️
Betrachtet man letzte 2 Monate, steigt nicht nur #Hospitalisierung bei #Kinderdurchseuchung, sondern auch bei 80+ sehr deutlich,
ebenfalls 60-79Jahre steigend, ähnliche Höhe wie #Hospitalisierungsinzidenz der 0-4Jährigen.
War das zu erwarten?➡️
Will the newly identified sub-lineages of #Delta may initiate a new wave of #Covid19 in India? What impact the increasing prevalence of the Delta-D clade would have on global #COVID burden?
My write-up deliberating on these issues in @TheWireScience 👇 science.thewire.in/the-sciences/a…
My write-up deliberating on these issues in @TheWireScience 👇 science.thewire.in/the-sciences/a…
Can #SARSCoV2 #variants fully evade #vaccine induced protection? Or even natural protection?
The rapid emergence of too many different #variants shows that the virus is struggling to survive! That is why it’s changing so fast, probably, to prolong its stay in human bodies 1/
The rapid emergence of too many different #variants shows that the virus is struggling to survive! That is why it’s changing so fast, probably, to prolong its stay in human bodies 1/
Though #vaccines may not be working perfectly against some #VOCs, but those fully vaccinated are protected against severe disease & death. No VOC can completely evade the vaccine induced protection, especially against severe disease & death! Why?.......... 2/
The #variants do not have changes in T-cell epitopes because when you are infected with a variant that evades an antibody, that variant can go to someone else and evade their antibody too. So it spreads through the population.... 3/
Our new preprint on the spread of the #SARSCoV2 variant Alpha in Geneva, Switzerland, and Beta in South Africa is online. We used clinical and epidemiological data to better understand the mechanisms that lead to a transmission advantage of the #VOCs. 1/8 doi.org/10.1101/2021.0…
When analyzing viral load in 950 individuals, we found that Alpha infections exhibit a higher viral load and longer viral shedding compared to non-VOC. 2/8
We then used a transmission model to study the following potential mechanisms that result in a transmission advantage: i) increase in transmissibility, ii) increase of infectious duration, and iii) immune evasion. 3/8
This 👇🏼 #Singapore seeing new large #COVID19 clusters, including #B1617 Changi Airport, Tan Tock Seng hospital. Shows a) #VOC import risk, b) better cluster tracking with low case numbers, c) now is not the time to relax measures 🇨🇭 (1/n) straitstimes.com/singapore/heal…
Response to #B1617 #SARSCoV2 In #Singapore govt 3-phase model has just reduced group sizes from 5 to 2 and stopped indoor dining. #Switzerland, with >1000 cases daily planning large relaxation 🙈 #PrecautionaryPrinciple please channelnewsasia.com/news/singapore…
Was machen bei steigenden Zahlen und bei wachsendem Anteil von VoC (Variants of Concern - besorgniserregende Varianten) wie #B117?
#ECDC gibt dazu klare Empfehlungen. Ob Hannovers OB @BelitOnay das gelesen hat vor Öffnungs-Forderungs-Paper Unterschrift?
H: Inz 115 & #B117 40-50%
#ECDC gibt dazu klare Empfehlungen. Ob Hannovers OB @BelitOnay das gelesen hat vor Öffnungs-Forderungs-Paper Unterschrift?
H: Inz 115 & #B117 40-50%
Hier nochmal zum im Thread bleiben die "Options for Response" der @ECDC_EU .
Quelle:
ecdc.europa.eu/en/publication…➡️
Quelle:
ecdc.europa.eu/en/publication…➡️
3/ Die Öffnungsforderung von 17 Oberbürgermeistern, darunter #Onay will das Gegenteil.➡️
haz.de/Nachrichten/De… via @HAZ
haz.de/Nachrichten/De… via @HAZ
