Discover and read the best of Twitter Threads about #UnequalRandomisation
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While 1:1 randomisation to interventions is most common in clinical trials, sometimes #UnequalRandomisation is used. There are a number of factors that influence which randomisation ratio to use 1/9
#MethodologyMonday
#MethodologyMonday
One justification for unequal randomisation is when there is a substantial difference in cost of treatments. In this scenario, randomising unequally with fewer to the very expensive arm maximises efficiency when a trial has set resources 2/9
bmj.com/content/321/72…
bmj.com/content/321/72…
Another is if you are undertaking an early investigation of a new treatment and need to have greater insights into its underlying safety/benefit profile. Here, increasing allocation to the new treatment will provide greater precision around these estimates 3/9
