Discover and read the best of Twitter Threads about #UCSFMGR
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1/ Starting now #UCSFMGR with @UCSFGIfellows @kpthrive Dr. Doug Corley on Updates on Colorectal Cancer Screening, esp w/ the latest controversial @NEJM NordICC trial: nejm.org/doi/full/10.10…
Dr. @Bob_Wachter opens w/ humorous Dave Barry quote re:colo: miamiherald.com/living/liv-col…
Dr. @Bob_Wachter opens w/ humorous Dave Barry quote re:colo: miamiherald.com/living/liv-col…
@UCSFGIfellows @kpthrive @NEJM @Bob_Wachter 2/ Dr. @DouglasCorley notes that there are many CRC deaths even w/ effective CRC screening - it's the 2nd leading cause of cancer death. Current screening modalities have different types of supporting evidence: FOBT, FIT test, septin-9 blood testing, sigmoidoscopy & colonoscopy. 
@UCSFGIfellows @kpthrive @NEJM @Bob_Wachter @DouglasCorley 3/ Digging into NordICC Methods: this was really an EFFECTIVENESS trial of INVITATION to a real-world implementation program. CRC screening is not only diagnostic, but also preventative & long lag time b/w dx & mortality. The study showed moderate uptake of colo - like US.
1/ Starting NOW on Zoom - welcome back to #UCSFMGR where we'll discuss vax, Paxlovid & all things COVID w/ Drs. @DrPaulOffit @SDoernberg & @annieluet moderated by @Bob_Wachter
2/ First up @DrPaulOffit: The goal of the vax is to protect against serious illness...To be protected against mild dz, you need high levels of neutralizing Abs at the time of exposure, which you would need fairly frequent boosters for. "I think one of the communication...
3/ ..mistakes was to use the term 'breakthrough:'mild illness means vax is working well..Similarly, rotavirus vax keeps babies out of the ICU & the vax is working well...This is a drifted virus, it's more like flu & the good news is that you're protected against serious illness."
1/ Welcome back to a COVID #UCSFMGR w/ local experts Drs @Rutherford_UCSF @SDoernberg @PCH_SF abt the latest Omicron surge & the changes in local & national policy. First, Dr. @Rutherford_UCSF will share the latest SF data & then expert panel w/ questions frm @Bob_Wachter to all
2/ Overall good news, but deaths continue to rise. "We have turned the corner nationwide, but make no mistake, there's a TON of infection out there, there are a ton of infectious people, and a ton of disease we're continuing to see." Note the deep purple map.
3/ Still highest cases in LA, ~20k cases per day. Bay Area is lightening. Re down to 0.6-0.7. Cases in Cali are falling but still very high, avg of 2-3K cases/day. Hospitalizations are still rising, not peaked yet in larger counties."65 deaths/day in LA frm COVID is not trivial."
1/ Wonderful don't-miss hour at #UCSFMGR with a candid COVID convo b/w Drs @ashishkjha & @Bob_Wachter. Dr @ashishkjha was a fmr @UCSFIMChiefs at the VA, a leading policy expert & is now a trusted #SciComm expert on all things COVID-related: the Walter Cronkite of our time.
2/ Boosters: FDA mtg today on Moderna. Jha says "POTUS mostly got it right" re: boosters. We still see v hi levels of protection w/ severe illness but even prevention of milder breakthru is important. Concentrate on high-risk ppl 1st. NOT a tradeoff w/vaxing the world/the unvaxed
3/ "We can do both!" says Jha. We already have ~90 mil doses sitting in states now & have to distribute those, can't rapidly logistically move doses frm your CVS to India. Actual # of booster doses is "drop in the bucket compared to global supply." Still need #GlobalVaccineEquity
1/ Welcome back to #UCSFMGR! We are so thrilled to have Drs. @PaulTurnerLab & @michaelmina_lab. 1st up, @PaulTurnerLab speculates, what factors make a virus more successful at infecting hosts? We learn lessons frm SARS, HIV & SIV, flu-can get more transmissible, evade immunity,..
2/ improve binding to cellular proteins or even infect diff cell types. SARS-CoV2 does some of these already...Good news? Perhaps it could evolve decreased virulence as shown in this paper in Science science.org/doi/10.1126/sc… Maybe more transmissible, but less virulent virus?
3/ Lots of interesting hypotheses as to why the virus is so virulent already, but lots more research to be done, & hard to predict how the virulence will evolve., no 🔮 Fascinating Q&A, lots to learn, but in the meantime, #GetVaccinatedNow to avoid those evolutionary pressures!
