Discover and read the best of Twitter Threads about #Tissue
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How precise are noisy #morphogen gradients in #tissue #patterning?
It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated!
Our new #devbio paper is out in @NatureComms: rdcu.be/cH8Fx
It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated!
Our new #devbio paper is out in @NatureComms: rdcu.be/cH8Fx
A methodological subtlety has previously led to overestimated positional errors of the morphogen gradients in the mouse neural tube. We reanalysed the noisy gradients and found that the positional information they can convey to cells is actually orders of magnitude more precise.
Also, morphogen gradients in differently sized tissues must not be pooled and rescaled to their mean length, or else an artificial positional error is added.
This is the most straightforward explanation for chronic symptoms in at least a subset of #LongCovid patients. Partly b/c if the #virus is still present its activity can directly contribute to other phenomena also being documented in LongCovid
2/ Persistence of #SARS-CoV-2 in tissue could lead to shedding of spike protein into blood, which can catalyze the ongoing formation of microclots and hyperactivated platelets
3/ Persistence of SARS-CoV-2 can lead to ongoing downregulation of interferon and/or T cell signaling by the virus, creating an optimal atmosphere for activation of EBV or other #pathogens normally controlled by such immunity
New preprint: The team did autopsies on 44 patients w/ #COVID-19 to map + quantify SARS-CoV-2 distribution, replication and cell-type specificity across the human body (including brain) from acute infection through over 7 months following symptom onset: researchsquare.com/article/rs-113…
Important paper 👉 A team in Tokyo took RNA-seq data from the Genomic-#Tissue Expression Project: a public resource created to study tissue-specific gene expression/regulation from 54 tissue types collected from 1000+ healthy individuals at autopsy: bmcbiol.biomedcentral.com/articles/10.11…
2/ They successfully identified 39 viral species in at least one tissue (tissue types included #brain, pituitary, esophagus, thyroid, #heart, breast, lung, kidney, adrenal gland, prostate, #nerve, adipose tissue, blood vessel, ovary, uterus etc)
3/ Viruses identified in the various tissue samples included EBV, HSV-1, Varicella, CMV, HHV6-A/B, HHV-7, HCV, HPV, adeno-associated virus...and 16 RNA #viruses including Respiratory syncytial virus (RSV), Parainfluenza Virus 3..
📢𝗦𝗲𝗿𝗶𝗲𝘀 𝗮𝗹𝗲𝗿𝘁!
We are thrilled to announce our new series #Tech4India as part of the #ETI in partnership with #NESTMEA @MEAIndia & @PrinSciAdvOff
Stay tuned for:
🔸Info on key #emerging technologies & sectors 📡🧬🚀⚛️ 🤖
🔸Details on participation in the #ETI
We are thrilled to announce our new series #Tech4India as part of the #ETI in partnership with #NESTMEA @MEAIndia & @PrinSciAdvOff
Stay tuned for:
🔸Info on key #emerging technologies & sectors 📡🧬🚀⚛️ 🤖
🔸Details on participation in the #ETI
#Tech4India
Recent advances in 𝗤𝘂𝗮𝗻𝘁𝘂𝗺 𝘁𝗲𝗰𝗵 can bring paradigm shifts in #computing #communication & #cryptography affecting all sectors in the process
Participate in #ETI & help India prepare for the #QuantumRevolution 2.0⚛️
ℹ️thesciencepolicyforum.org/initiatives/et…
#NESTMEA
1/2
Recent advances in 𝗤𝘂𝗮𝗻𝘁𝘂𝗺 𝘁𝗲𝗰𝗵 can bring paradigm shifts in #computing #communication & #cryptography affecting all sectors in the process
Participate in #ETI & help India prepare for the #QuantumRevolution 2.0⚛️
ℹ️thesciencepolicyforum.org/initiatives/et…
#NESTMEA
1/2
#Tech4India
We encourage people from varied backgrounds to form multidisciplinary teams and send us EoI on innovations like #QuantumComputing #QuantumCommunication & #QuantumNetworks
Selected teams will be invited to prepare a consolidated tech dev & adoption roadmap 4 🇮🇳
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We encourage people from varied backgrounds to form multidisciplinary teams and send us EoI on innovations like #QuantumComputing #QuantumCommunication & #QuantumNetworks
Selected teams will be invited to prepare a consolidated tech dev & adoption roadmap 4 🇮🇳
2/2
Thanks for sharing my perspective in this piece @MeganEDoherty! As I mention, in these #longcovid cases, it’s very important to take the potential persistence of #COVID-19 in certain tissues and/or the central nervous system (CNS) seriously!
2/ That’s b/c #Coronaviruses have been shown capable of persisting in human #tissue or certain “anotomical sanctuaries” - for example, this team found Coronavirus RNA + antigen in the Multiple Sclerosis brain: ncbi.nlm.nih.gov/pmc/articles/P…
3/ Also in other “post-viral” syndromes like “Post-#Ebola Syndrome, viral RNA has been found in unexpected body sites like sperm, or the eyes, years after initial infection: nejm.org/doi/full/10.10…
Cool new study which found that a range of #pathogens (some capable of long-term persistence in tissue + #blood) upregulate expression of the cell surface protein CD47 in the host cells they infect as an #immune evasion strategy
2/ I fact, upregulation of CD47 is a very smart survival strategy by such pathogens, b/c it interferes w/ the host innate immune response that is normally supposed to identify, target and kill them!
@jenbrea Hey! Yes several people spoke on that topic at the recent #ILADs conference I was at 👉 and remember this case history which found that a woman treated w/ antibiotics to target persistent #Bartonella had substantial improvement in EDS symptoms: ncbi.nlm.nih.gov/pmc/articles/P…
@jenbrea 2/2 As for #mast cell activation in response to persistent #pathogens...there is extensive literature on how a range of bacterial, viral and fungal pathogens can drive #MCAS-like symptoms 👉 for example: ncbi.nlm.nih.gov/pmc/articles/P…
@jenbrea 3/3 There is even a receptor common in #connective tissue who’s activity controls mast cell activation in response to bacterial signaling molecules that drive #biofilm formation: ncbi.nlm.nih.gov/m/pubmed/31278…
