Discover and read the best of Twitter Threads about #Sisonke

Most recents (24)

[THREAD] Wondering what to make of the @US_FDA’s new rules about the J&J vaccine? Here’s what you need to know.
America’s medicines regulator announced that the J&J jab should only be given to adults in 3 scenarios: bit.ly/3lfRb5p
1. They don’t have access to other #COVID jabs.
2. They can’t take other #COVID #vaccines for medical reasons.
3. They choose the J&J jab because it’s the only vaccine available.
Read 17 tweets
🧵1. Will SA vax kids between 5 + 11 years @ #COVID19?
- The vax MAC = not made a recommendation 2 @HealthZA. @SAHPRA1 = not approved vax 4 this group yet
- But if they say "yes" = no money 2 buy the jabs. Kids jabs = different from adult jabs. We can't use the ones we've got.
2. Do other countries vaccinate kids between 5 + 11 @ #COVID19?

- Just over a quarter of kids between 5 + 11 = vaxxed in the US
- UK = vaxxing vulnerable kids (for now)
- Sweden = only vaxxing kids vulnerable to respiratory diseases
- Full story: bit.ly/3JVGmzu Image
3. What about our current #COVID19 vax stock?
- In total we've got 27 million doses
- 400,000 #Pfizer doses will expire on March 31
- 7 million #Pfizer doses will expire in June/July
- Full podcast: bit.ly/3BYCFqc
Read 10 tweets
JUST IN [Thread] 1. Early findings from 2 SA studies suggest #Omicron has a much higher rate of asymptomatic "carriage" (#COVID19 without symptoms) than previous variants and this is likely an important reason why the variant spreads so fast.
Preprint: bit.ly/3q8NykS
2. Which studies are findings based on?
1. Ubuntu: A sub-Saharan #Africa study that measures the effectiveness of #Moderna's #COVID19 jab in #HIV+ people (all initial sites in SA)
2. A sub-study of #Sisonke, conducted among SA #HealthWorkers, that measures #JnJ's effectiveness
3. Neither of the studies = designed 2 look @ asymptomatic infections specifically, rather 2 measure breakthrough infections, immunogenicity + effectiveness of jabs in HIV+ and other groups, but they do give useful info on how #Omicron's spread differs from other variants.
Read 9 tweets
JUST IN #VaccineRollOutSA stats: Thu, 6 Jan
1/4

1. Jabs, past 24 hrs: 65,204
18+: 49,307
12-17: 15,897

2. All doses (since the start of the roll-out in May 2021): 28,233,512

3. SA population = fully vaccinated:
15,783,311 (26.2%)

(SA pop = 60.14 mil, Stats SA, 2021)
2/4

ADULTS
1. How many adults (18+) have been fully vaccinated (1 dose #JnJ/2 doses #Pfizer)?
15,737,760 (39.2%)

2. How many adults (18+) have been vaccinated (1 dose of JnJ/1 dose Pfizer)
17,957,898 (44.8%)

(18+ pop = 40.12 mil, Stats SA, 2021)
3/4

TEENS
1. 12-17, #Pfizer (teens can only get Pfizer so far)
All doses: 963,184
1st dose: 917,633
(So 14.1% of the 12-17 population = vaccinated)

2nd dose: 45,551
(So 0,7% of the 12-17 population = fully vaccinated)

(12-17 pop = 6.5 million, Stats SA, 2021)
Read 4 tweets
LATEST 2022 #VaccineRollOutSA stats: We, 5 Jan
1/4

1. Jabs, past 24 hrs: 64,724
18+: 49,784
12-17: 14,940

2. All doses (since the start of the roll-out in May 2021): 28,164,339

3. SA population = fully vaccinated:
15,744,496 (26.2%)

(SA pop = 60.14 mil, Stats SA, 2021)
2/4

ADULTS
1. How many adults (18+) have been fully vaccinated (1 dose #JnJ/2 doses #Pfizer)?
15,702,030 (39.1%)

2. How many adults (18+) have been vaccinated (1 dose of JnJ/1 dose Pfizer)
17,926,267 (44.7%)

(18+ pop = 40.12 mil, Stats SA, 2021)
3/4

TEENS
1. 12-17, #Pfizer (teens can only get Pfizer so far)
All doses: 947,167
1st dose: 904,701
(So 13.9% of the 12-17 population = vaccinated)

2nd dose: 42,466
(So 0,65% of the 2-17 population = fully vaccinated)

(12-17 pop = 6.5 million, Stats SA 2021)
Read 4 tweets
[Thread] 1. Will @HealthZA achieve its latest #VaccineRollOutSA goal by the end of 2021 (today)?

No.

What's the goal?
Vaccinating 70% of people of 50+ with 1 shot of #Pfizer or #JnJ by midnight, 31 Dec 2021.

Where are we at? 64.08% (so 5.92% short of the 70% goal)
2. Is 64.08% of people of 50+ vaccinated the final figure for 2021?

No, we'll get the vax figures for today (31 Dec) tonight.

But it's unlikely to make much of a difference to the overall %, as we're currently doing fewer than 50,000 doses per day.
3. What's the breakdown for the different 50+ age groups (for 1 jab per person)?

60+: 66.08% (we've covered 3.6 mil out of a 60+) population of 5.5 mil)
50-59: 61.78% (we've covered 2.9 mil out of a 50-59 population of 4.8 mil)
Read 10 tweets
JUST IN [Thread]:
1. @HealthZA disagrees with the US government's CDC's decision to recommend #mRNA jabs above #JnJ (because of rare side effects) - we'll continue using JnJ
2. The US = abundance of jabs (100 mil + ready for use), so they can afford 2 be choosy.
2. How safe is #JnJ?
1. @MRCza analysed safety data from the #Sisonke study (which uses #JnJ)
2. Serious side effects were rare and occurred in only 129 out of about 500 000 #HealthWorkers in the study
3. What does #Sisonke data tell us about mild #JnJ side effects?
1. The commonest side effects = headache, body aches, pain @ injection site, fever
2. Most side effects = occurred within 48 hours of vaccination
Read 6 tweets
BREAKING [Thread] 1. @SAHPRA1 has approved a 2nd dose of #JnJ and heterologous (mix/match) booster for adults:

1. If u had a JnJ jab, u can get a booster @ least 2 mnths after 1 JnJ shot
2. If u had a #Pfizer jab, u can get a JnJ booster @ least 6 mnths after a 2nd Pfizer jab
2. Does @SAHPRA1's approval mean you can have a #Pfizer booster after a #JnJ shot?

NO. It’s only the other way around (a #JnJ booster after a 2nd #Pfizer shot) that has been approved as a “mix and match” booster.
3. Why does @sahpra1’s “mix and match” approval not allow for a #Pfizer booster after a #JnJ shot?

Pfizer hasn’t submitted data to Sahpra for approval (#JnJ submitted the data 4 a #JnJ booster after #Pfizer).
Read 18 tweets
A few #Sisonke study updates. There are three pre-print publications out now, for those interested: 1. Effectiveness data on the single dose JnJ Ad26.COV2.S vaccine 2. Safety of the JnJ vaccine and 3. Breakthrough infections during Omicron wave @CAPRISAOfficial @MRCza @HealthZA
1. Effectiveness: VE to prevent deaths 83%, ITU admissions 75% and hospitalisations 67%. VE maintained for older HCWs, those with comorbidities or living with HIV, through beta and delta waves papers.ssrn.com/sol3/papers.cf…
2. Safety: Generally safe. 2.2% of 477234 Sisonke participants reported AEs vast majority mild (commonest headaches & body aches & fever). Few serious AEs (N=139), but below expected population rates. Two cases of TTS and recovering. medrxiv.org/content/10.110…
Read 4 tweets
What is happening with #COVID19 vaccine boosters + when will SA start?

[Thread]

Nicholas Crisp, @heatlhza:
1. #Pfizer boosters = given 6 mnths after the 2nd dose (that's what Sahpra approved)
2. 1st person = qualify on 28 Dec, @healthza = on that day/shortly thereafter
2. Nicholas Crisp:
1. People who got vaccinated 1st will get boosters 1st because of the 6 month period that need to lapse after the 2nd dose
2. So if you're 50 and went for your Pfizer vaxx before someone who is 60, you will get your booster before the 60 year old person
3. Will SA shorten the 6 month period for a #Pfizer booster after the 2nd dose like some other countries?
1. Sahpra has approved 6 months (not shorter)
2. But Sahpra is looking into data for shorter periods, will announce decision when there's clarity
Read 5 tweets
[Thread] 1. What's happening with #COVID vaccine boosters in SA?

Nicholas Crisp, @heatlhza:
1. SA = not yet vaccinated enough people to focus on boosters for large groups of people
2. HCWs = special group as they get exposed to #COVIVD19 more so their infection risk = higher
2. Crisp:
1. Some #HealthWorkers vaccinated in the #Sisonke trial were vaccinated 8 months ago, so they may need booster shots
2. They will receive 2nd #JnJ doses in a study starting in Nov
3. What about people with weak immune systems who may need boosters?
Crisp:
The MAC has advised that people with a specific set of immunocompromised conditions get a 3rd #Pfizer/2nd #JnJ dose 28 days after they were fully vaccinated. This is not a booster, but an extra dose.
Read 8 tweets
[THREAD] 1. What type of booster dose will #Sisonke trial participants (health workers) receive?

A 2nd #JnJ shot (they all received a first #JnJ shot).
2. Will #Sisonke trial participants (#HealthWorkers) receive their booster doses as part of a trial/study?

YES. There will be a 2nd Sisonke study.
3. Where will the booster doses for #Sisonke trial participants come from? #JnJ will donate research doses (they did this for the first study too).
Read 5 tweets
[Thread] 1. How are we doing with #JnJ supply?

Here's what @healthza says we've received so far:

4 June – 300,000 (short expiry)
21 June – 1,253,600 (short expiry)
26 July – 1,454,400
9 August – 619,200
6 September – 1,413,600
13 September – 1,360,800
TOTAL – 6,401,600
2. How many doses does #JnJ still owe us?
We procured 31.2 million doses, so:
31,200,000 - 6,401,600 = 24,798,400
3. When will the rest of our #JnJ stock arrive?

Janssen/#JnJ = given @healthza tentative delivery dates for Sep + Oct, but the dates = not public.

But the quarterly delivery schedule is public:
Q3 (July - Sep): 9,100,000 doses
Read 12 tweets
Ich werde immer gefragt, wie gut denn der Schutz einer Johnson&Johnson Impfung gegen die Delta Variante ist. Hier nun endlich Studiendaten dazu und Erklärung auf Deutsch im 🧵
Die Studie heißt #Sisonke und es wurden Krankenhausangestellte geimpft.
Schutz vor Tod durch schwere Corona Infektion ist wie bei den anderen Impfstoffen mit rund 95% sehr hoch. Image
Schutz vor Krankenhauseinweisung aufgrund von einer Infektion mit Delta ist 72%, bei Beta nur 67%. Das ist gut, aber AstraZeneca und mRNA haben da bessere Effektivitäten. Image
Read 5 tweets
[Thread] 1. Glenda Gray, co-lead investigator, #Sisonke:

We now have results to show the #JnJ jab provides significant protection @ the #DeltaVariant in SA.

What is Sisonke?

The Sisonke study used the #JnJ jab to look @ the effectiveness of the jab among SA #HealthWorkers
2. Gray:
1. #Sisonke vaccinated 477 234 #HealthWorkers
2. 122 sites were used to vaccinate health workers
3. Gray:
#Sisonke researchers used three sets of data to analyse the study's results:
1. 2 sets of data from medical insurers were used and one set of provincial persal data
2. Today Gray is only reporting on two sets of data
Read 11 tweets
[Thread] 1. Are the 5.6 mil #Pfizer doses the US gov is donating to SA in addition to the Pfizer doses we've already procured ? YES (confirmed by @healthza)
2. How many #Pfizer doses has SA received up until now (so doses we've bought/paid for)?
@healtza figures:

Pfizer (bilateral deal): 6, 606, 990
Pfizer via #COVAX: 1, 392, 300

TOTAL: 7, 999, 290
3. How many #JnJ doses has SA received so far (without #Sisonke's JnJ research doses)?

@healthza figures:
1, 553, 600
(1, 49 million doses will be at clinics next week — these are the doses released by Aspen to #JnJ on Monday)
Read 4 tweets
[Thread] Glenda Gray, @MRCza:
1. The only way to bring the #COVID19 pandemic under control, is to vaccinate a large % of SA
2. Everyone needs to be vaccinated, not just 20%/30% of the population
3. Only 1.1% of people in low income countries have received one #CovidVaccine dose
2. Glenda Gray:
1. The benefits of vaccines far outweigh the occurrence of side effects
2. Severe side effects, such as rare/unique types of blood clots associated with #JnJ and heart inflammation associated with #Pfizer are very uncommon
3. Glenda Gray: How rare is rare?
1. For #JnJ, rare blood clots = 3 cases for every mil doses among adults
2. For JnJ, Guillain-Barre syndrome = 7.8 cases for every million doses among adults

* What is Guilain-Barre syndrome? Find out here: mayocl.in/3wZWqJV
Read 13 tweets
JUST IN #VaccineRollOutSA stats (Sunday, 10 Jul):
[Thread]
1. Total doses (#JnJ, #Sisonke, #Pfizer) = 4, 236, 718
2. People = fully vaccinated = 1, 355, 743
3. Doses in the past 24 hours: 7, 824

Fun fact: KZN did the most Sunday vaccinations at public sites — by far.
2. Total doses (#JnJ, #Sisonke, #Pfizer): 4, 236, 718

How many are Pfizer doses?
* Total: 3, 333, 703
Breakdown:
* 1st dose: 2, 880, 975
* 2nd dose: 452, 728

How many are JnJ doses?
* Total: 903, 015
Breakdown:
* Sisonke: 483, 841
* Roll-out: 419, 174
3. How many people in SA have been fully vaccinated?
Total: 1, 355, 743
Breakdown:
* JnJ: 903, 015 (you only need 1 dose)
* Pfizer: 452, 728 (these people have all had 2 Pfizer doses)

Fully vaccinated: 903, 015 (JnJ) + 452, 728 ( (Pfizer 2nd dose) = 1, 355, 743
Read 4 tweets
[Thread] 1. JUST IN #VaccineRollOutSA stats (SA, 10 Jul):

1. Total doses (#JnJ, #Sisonke, #Pfizer) = 4, 225, 021
2. People = fully vaccinated (JnJ/ 2 Pfizer doses) = 1, 352, 213
3. Doses in the past 24 hours: 16, 005 (widely administered weekend doses will start on 1 Aug)
2. Total doses (#JnJ, #Sisonke, #Pfizer): 4, 225, 021

How many are Pfizer doses?
* Total: 3, 323, 573
Breakdown:
* 1st dose: 2, 872, 808
* 2nd dose: 450, 765

How many are JnJ doses?
* Total: 901, 448
Breakdown:
* Sisonke: 482, 515
* Roll-out: 418, 933
3. How many people in SA have been fully vaccinated?
Total: 1, 352, 213
Breakdown:
* JnJ: 901, 448 (you only need 1 dose)
* Pfizer: 450, 765 (these people have all had 2 Pfizer doses)

Fully vaccinated: 901, 448 (JnJ) + 450, 765 ( (Pfizer 2nd dose) = 1, 352, 213
Read 4 tweets
[Thread] 1. LATEST #VaccineRollOutSA stats (Fri, 9 Jul):

1. Total doses (#JnJ, #Sisonke, #Pfizer) = 4, 203, 293
2. People = fully vaccinated (JnJ/ 2 Pfizer doses) = 1, 344, 690
3. Doses in the past 24 hours: 175, 740 Image
2. Total doses (#JnJ, #Sisonke, #Pfizer): 4, 203, 293

How many are Pfizer doses?
* Total: 3, 305, 614
Breakdown:
* 1st dose: 2, 858, 603
* 2nd dose: 447, 011

How many are JnJ doses?
* Total: 897, 679
Breakdown:
* Sisonke: 480, 495
* Roll-out: 417, 184 Image
3. How many people in SA have been fully vaccinated?
Total: 1, 344, 690
Breakdown:
* JnJ: 897, 679 (you only need 1 dose)
* Pfizer: 447, 011 (these people have all had 2 Pfizer doses)

Fully vaccinated: 897, 679 (JnJ) + 447, 011 (Pfizer 2nd dose) = 1, 344, 690
Read 4 tweets
[Thread] 1. LATEST #VaccineRollOutSA stats (8 Jul):

* We've crossed the 4-mil mark for doses given + data is now broken down (Pfizer 1st/2nd dose, JnJ) *

1. Total doses (#JnJ, #Sisonke, #Pfizer) = 4, 017, 442
2. People = fully vaccinated (JnJ/ 2 Pfizer doses) = 1, 253, 978
2. Total doses (#JnJ, #Sisonke, #Pfizer): 4, 017, 442

How many are Pfizer doses?
* Total: 3, 141, 867
Breakdown:
* 1st dose: 2, 763, 464
* 2nd dose: 378, 403

How many are JnJ doses?
* Total: 875, 575
Breakdown:
* Sisonke: 479, 949
* Roll-out: 395, 626
3. How many people in SA have been fully vaccinated?
Total: 1, 253, 978
Breakdown:
* JnJ: 875, 575 (you only need 1 dose)
* Pfizer: 378, 403 (these people have all had 2 Pfizer doses)

Fully vaccinated: 875, 575 (JnJ) + 378, 403 (Pfizer 2nd dose) = 1, 253, 978
Read 5 tweets
[Thread] 1. GOOD NEWS about vaccine acceptance: MORE people in SA are now willing to be vaccinated. The latest results from @NIDS_CRAM show:
1. In Feb/March 71% of SAs said they'll consider being vaccinated.
2. In April/May this had increased to 76%.
2. Where does this info come from?
1. About 5000 study participants got asked to respond to the same statement in Feb/March and April/May
2. Statement = "If a vaccine for #COVID19 were available, I would get it."
2. When?
* 2 Feb to 1 March
* 6 April to 11 May
3. You can see the increase in vaccine acceptance here. Acceptance = "strong agreement" (green) + "some agreement" + "been vaccinated" (aquamarine):
1. Feb/March: 55% (green) + 16% (light green) = 71%
2. April/May: 64% (green) + 10% (light green) + 2% (aquamarine) = 76%
Read 13 tweets
[Thread] 1. Glenda Gray, @MRCza: How effective are different #COVID vaccines @ the Beta variant (B.1.351)?
* #JnJ: 64%
* Novavax: 48.6%
* AstraZeneca: 10%
2. Early lab data shows that the #JnJ vaccine works against both the Beta and Delta variants, but better against the #DeltaVariant.
3. Do we need to boost the #JnJ vaccine with a second shot (currently you only get one shot)? Not yet. Data shows that an immune response is maintained over time from a single shot for up to eight months after vaccination.
Read 5 tweets
[Thread]. 1. How do you find #VaccineRolloutSA stats? There's a dashboard: bit.ly/3jbNiyp
1. The timeframe used to report vaccinations has changed
2. Previous time frame = jabs of previous day
3. New timeframe = jabs of previous day, 5:01pm to jabs of current day: 5pm
2. Anyone can access the #VaccineRolloutSA dashboard:
1. The dashboard will be updated each day, by the latest 6:30pm
2. The dashboard will sometimes also be updated through the course of the day
3. From the dashboard: this table shows the nr of jabs done between June 23 5:01pm - June 24 5pm
* The nr 115 016 includes ALL vaccinations of the past 24 hours (at normal sites, special sites [e.g. teachers] + work places, regardless of the type of jab (JnJ or Pfizer) used
Read 6 tweets

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