Discover and read the best of Twitter Threads about #SIRENStudy
Most recents (8)
Latest #SIRENStudy paper:
Effectiveness of BNT162b2 mRNA vaccine third doses and previous infection in protecting against SARS-CoV-2 infections during the Delta and Omicron variant waves; the UK SIREN cohort study September 2021 to February 2022
medrxiv.org/content/10.110…
Effectiveness of BNT162b2 mRNA vaccine third doses and previous infection in protecting against SARS-CoV-2 infections during the Delta and Omicron variant waves; the UK SIREN cohort study September 2021 to February 2022
medrxiv.org/content/10.110…
During Delta period:
278 primary infections (4/10,000 person-days follow-up)
85 reinfections (0.8/10,000)
During Omicron period:
2,467 primary infections (43/10,000)
881 reinfections (33/10,000)
278 primary infections (4/10,000 person-days follow-up)
85 reinfections (0.8/10,000)
During Omicron period:
2,467 primary infections (43/10,000)
881 reinfections (33/10,000)
Relative vaccine effectiveness 0-2 months post-3rd (Pfizer) vaccine in SARS2 naïve cohort during Delta: 63 (95 % CI 40, 77) %
During Omicron:
35 (95 % CI 21, 47) %
During Omicron:
35 (95 % CI 21, 47) %
Got some blood test results back from a #SIRENstudy sub-study @vibrant_uk
They're trying to understand if there's immunological factors that prevent some people getting infected (among other things). 🧵
They're trying to understand if there's immunological factors that prevent some people getting infected (among other things). 🧵
As a "never infected" participant, I got to partake. though my infection status is due to FFP3 & living a fairly isolated disabled life rather than my immune system being super awesome
tho clearly my immune system is a bit wonky
#postvac #vaccineinjuries
tho clearly my immune system is a bit wonky
#postvac #vaccineinjuries
anyway, all normal:
IgG 8.2 g/L (ref: 6-16)
IgA 2.5 g/L (0.8-4)
IgM 1.2 g/L (0.5-2)
suggests no signs of autoimmunity, in line with all the negative autoimmune tests i've had, except the questionable CellTrend ones
IgG 8.2 g/L (ref: 6-16)
IgA 2.5 g/L (0.8-4)
IgM 1.2 g/L (0.5-2)
suggests no signs of autoimmunity, in line with all the negative autoimmune tests i've had, except the questionable CellTrend ones
🚨🚨New #SIRENstudy preprint 🚨🚨
Not yet peer reviewed.
papers.ssrn.com/sol3/papers.cf…
A 🧵 1/n
@victoria_jhall @bealelab @SMHopkins
Not yet peer reviewed.
papers.ssrn.com/sol3/papers.cf…
A 🧵 1/n
@victoria_jhall @bealelab @SMHopkins
First up thank you to the amazing participants in #SIRENstudy 🙏 Without you, no study. NHS staff continuing to go above and beyond in really challenging times 🤩 #notAllHeroesWearCapes
And, of course, our thanks to the NHS sites across all 4 countries!
2/n
And, of course, our thanks to the NHS sites across all 4 countries!
2/n
We wanted to find the correlate of protection (CoP) against Delta infection.
No study so far has managed this.
Aficionados might want to skip ahead: papers.ssrn.com/sol3/papers.cf…
3/n
No study so far has managed this.
Aficionados might want to skip ahead: papers.ssrn.com/sol3/papers.cf…
3/n
very happy as we've been sending out #SIRENstudy participants at our site their spike antibody results. today i received mine, and OHHH BOOOOYYYYY are they interesting!
but first, some context 🧵
#postvac #vaccineinjuries #LongCovid #TeamClots
but first, some context 🧵
#postvac #vaccineinjuries #LongCovid #TeamClots
i will start by saying that all my nucleocapsid antibodies are unambiguously negative. each blood sample is accompanied by a PCR + another PCR in between blood samples. + a 3rd PCR a month for ONS.
the numbers. we use the Abbott IgG immunoassay which has a maximum threshold of 80,000 AU/mL. below is the information we have given to participants 
🎈🎈Happy Birthday #SIRENStudy - the study opened 2 years ago & recruited ~45,000 healthcare workers for follow- up to study the impact of #COVID19 prior infection on re-infection; it then was modified to discuss the impact of #vaccination and #variants
ukhsa.blog.gov.uk/2022/06/20/the…
ukhsa.blog.gov.uk/2022/06/20/the…
Highlighting key papers
SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)
The Lancet 397 (10283), 1459-1469
ncbi.nlm.nih.gov/pmc/articles/P…
SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)
The Lancet 397 (10283), 1459-1469
ncbi.nlm.nih.gov/pmc/articles/P…
COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study
The Lancet 397 (10286), 1725-1735
ncbi.nlm.nih.gov/pmc/articles/P…
The Lancet 397 (10286), 1725-1735
ncbi.nlm.nih.gov/pmc/articles/P…
I lead the #SIRENStudy and have been studying the impact of prior infection with COVID-19 and COVID-19 vaccinations on immunity for more than 18 months. We have published multiple studies with collaborators. The most recent preprint is available here medrxiv.org/content/10.110… 1/6
In this pre-print, which is under peer review, we demonstrate that 2 doses of vaccination on top of prior of infection, significantly reduces both asymptomatic & symptomatic infection compared to infection alone - Table 3 - the longer since primary infection the more effect 2/6
This is on top of the evidence provided in the original paper showing immunity 81-87% immunity with the original strains and early alpha period.... but just as immunity wanes from vaccines so it does from primary infection. 3/6
pubmed.ncbi.nlm.nih.gov/33844963/
pubmed.ncbi.nlm.nih.gov/33844963/
1/Our PITCH consortium preprint on immune responses during different Pfizer BNT162b2 dosing regimens is out! pitch-study.org TL;DR get both doses of whichever vaccine you are offered
2/Led by @rebecca37704429 and @Susannajd with Paul Klenerman and Miles Carroll (not on twitter!)@DHSCgovuk @UKCICstudy @PHE_uk @stephanie200586 @chrisjaduncan @EleanorBarnesOx @AlexRichter3 @sarahlrj @LanceTurtle and more!
3/Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the UK to accelerate population coverage with a single dose. Recruiting 503 healthcare workers across 5 UK centres, we set out to answer some questions...
Our paper on immune responses to COVID vaccine (mostly Pfizer) in 237 healthcare workers, 124 #SARSCoV2 naïve and 113 previously infected, from the PITCH consortium @pitchstudy is out as a pre-print today.
papers.ssrn.com/sol3/papers.cf…
@pitchstudy
@DHSCgovuk
@UKCICstudy
@PHE_uk
1/16
papers.ssrn.com/sol3/papers.cf…
@pitchstudy
@DHSCgovuk
@UKCICstudy
@PHE_uk
1/16
We already know from the @PHE_uk #SIRENstudy that Pfizer vaccine is protective in healthcare workers. In this paper, we investigate possible mechanisms of protection. 2/17
