Discover and read the best of Twitter Threads about #Rituximab

Most recents (6)

RITAZAREM ➡️ Rituximab (RTX) versus azathioprine (AZA) for maintenance of remission for patients with ANCA-associated vasculitis (ANCA-AV) and relapsing disease.

👀Thread👀

#vasculitis #rituximab #MedEd

ard.bmj.com/content/early/…
Design:
- Open label, randomized.
- Patients with relapsing GPA or MPA, ANCA +.
- Induction phase (4 months): RTX 375 mg/m2x4 doses.
- Maintenance phase (4-24 months). Randomized to RTX (1 gram every 4 months, 5 doses) vs AZA (2 mg/kg).
- Follow-up phase (12-24 months). Image
Results:
- 170 patients randomized.
- 72% anti-PR3 and 28% anti-MPO. 62% severe relapse on entry into trial.
- Glucocorticoid (GC) induction: 28% 1 mg/kg/day and 72% 0.5 mg/kg/day.
- 78% prior treatment with cyclophosphamide!
Read 7 tweets
El futuro de las terapias #biológicas en #Sjögren
Dra. Soledad Retamozo
👀👄💧🩻🫁🩺💊💉🧪
#25TenTopicsBCN #TenTopics
Baja dosis de IL-2 en #Sjögren
👀👄💧🩻🫁🩺💊💉🧪 #IL2
#25TenTopicsBCN #TenTopics
#Baminercept en #Sjögren
👀👄💧🩻🫁🩺💊💉🧪
#25TenTopicsBCN #TenTopics
Read 9 tweets
”Det här blir en slags skenriktlinjer när jurister bestämmer vilken vetenskap som ska ingå i ett kunskapsunderlag.”
Oacceptabelt anser prof Anders Svenningsson som avgår som ordf i proriteringsgruppen MS.
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#offlabel @dagensmedicin

dagensmedicin.se/alla-nyheter/n…
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Mer om sakfrågan #rituximab vis #MS och #offlabel här i @lakartidn i oktober.
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lakartidningen.se/aktuellt/nyhet…
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Särskilt intressant följande i @lakartidn artikel från i oktober.
lakartidningen.se/aktuellt/nyhet…

Historien upprepar sig.
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Read 13 tweets
Ein Thread zu #Covid19 #Immunsuppression mit Medikamenten.

Es gibt inzwischen aussichtsreiche Behandlungsoptionen selbst für die am stärksten gefährdeten Gruppen. Allerdings sind die nicht ohne Probleme.
Wie der Stand ist und worauf ihr achten müsst.

1/15
Daten zeigen, dass die meisten Immunschwachen nach 3 Impfungen einen ordentlichen Schutz aufbauen. Z.B. 60% Serokonversion nach 2 Impfungen bei Krebs. Weitere Impfungen steigern die Serokonversion, d.h. auf jeden Fall 3. & 4. Dosis holen.
2/15

bmj.com/content/376/bm…
Bei zwei Gruppen wirken die Impfungen kaum: Organtransplantierte und Leute, die das Medikament #Rituximab bekommen.
Da gibt es aber inzwischen auch Optionen. Primär sind das monoklonale #Antikörper, die in DE nach meinen Infos weithin mit gutem Erfolg eingesetzt werden.
3/15
Read 15 tweets
1/ Classic #opticneuritis is characterized by a sub-acute loss of vision in one Eye, with central #scotoma, pain on #eyemovement, positive #RAPD
- Fundus exam is usually normal
- Age range 15-45 years
2/Talking about #MOGAntibodies:
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
Read 10 tweets
Let’s do a quick one on #clinicaldecisionmaking and #neuroimaging. See bright spot on MRI T2 Brain just means increased water -could be any insult to the brain - #infection #inflammation #ischemia #neoplasm are the top 4 you gotta have in your brain. Pun intended. #MedTwitter
Then you think - active or inactive process? If it’s actively destroying the BBB, it’ll enhance on contrast enhancement. So get MRI with and without contrast. Why without? T2 shine-through - but that’s for another time. #MedStudentTwitter #neurology #neurologyresident
Now the important question here is what you do - remember that nice poem on #theroadnottaken by #robertfrost? 2 widely diverging choices - to immunosuppress or not to immunosuppress. #tobeornottobe #hamlet #MedTwitter #AcademicTwitter #MedStudentChat
Read 13 tweets

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