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Pancreatic exocrine insufficiency: causes, consequences, diagnosis and treatment.
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Pancreatic juice is composed by
- Acinar secretion, rich in enzymes
- Ductal secretion: A) Water that will help to flush the acinar secretion B) Bicarbonate that will neutralize gastric acid in the duodenum; some enzymes like lipase do not work in an acid environment
- Acinar secretion, rich in enzymes
- Ductal secretion: A) Water that will help to flush the acinar secretion B) Bicarbonate that will neutralize gastric acid in the duodenum; some enzymes like lipase do not work in an acid environment
The arrival of acid and protein products to the duodenum induce S-cells to produce secretin which stimulates ductal secretion. Fatty acids, amino-acids and vagus nerve induce I-cells to produce cholecystokinin (CCK) which stimulates acinar secretion
