Discover and read the best of Twitter Threads about #OmegaFold
Most recents (1)
Pretty wild that there have been at least 4-5 antibody-specific structure prediction tools this year, all based on #deeplearning
1. DeepAb/IgFold (@jeffruffolo)
2. ABLooper/ImmuneBuilder (@brennanaba)
3. Equifold (@jaehyeon_lee_ml)
4. t-AbFold
What does this mean? 🧵(1/6)
1. DeepAb/IgFold (@jeffruffolo)
2. ABLooper/ImmuneBuilder (@brennanaba)
3. Equifold (@jaehyeon_lee_ml)
4. t-AbFold
What does this mean? 🧵(1/6)
First, it's pretty crazy we even have antibody-specific tools, since #AlphaFold2, #ESMFold, #OmegaFold, all do a decent job at antibody modelling. However, antibody-specific tools have -some- feature that's necessary (e.g. being MSA-free) (2/6)
The demand is likely due to interest from pharma & biotech, but we don't have anywhere near the same level of interest for other polymorphic proteins like TCRs and MHCs (🤔). Regardless, with such interest, I think an antibody-specific CASP should be resurrected! (3/6)
