Discover and read the best of Twitter Threads about #MTHFR
Most recents (2)
1st, what a sloppy claim. The hypothesis that intracellular folate deficiency can cause symptomatic elements of #EDS is not new, but I think it's wrong. The #MTHFR polymorphism is SO common and we've gone down the MTHFR rabbit hole before. /1
You hypothesis is that decreased activation of decorin causes structural differences in collagen making it loose enough to cause hypermobility. I find it interesting that other, peer-reviewed studies say that "decorin promot[es] inflammatory activity" science.org/doi/abs/10.112… /2
suggesting that a decrease in decorin could actually be protective in disease associated with an inflammatory state, such as #EhlersDanlos. That is not to say that treating patients with the MTHFR polymorphism with methylfolate couldn't cause improvement, but /3
#MTHFR – THE IATROGENIC GENE??
#MTHFR discovered in mid-1990's.
#MTHFR plays essential role in DNA and protein methylation-important epigenetic mechanism used by cells to control gene expression.1/
#MTHFR discovered in mid-1990's.
#MTHFR plays essential role in DNA and protein methylation-important epigenetic mechanism used by cells to control gene expression.1/
Pharmacogenomics studies the relationship between genetic variations and how our body responds to medications.2/
What happens when things go wrong?
Defective imprinting mechanisms/abnormalities in methylation can result in predisposition to diseases–cancer,muscular dystrophy,cardiovascular diseases, Alzheimer's,autism,rheumatoid arthritis,pregnancy complications,leukemia,various neoplasms.
Defective imprinting mechanisms/abnormalities in methylation can result in predisposition to diseases–cancer,muscular dystrophy,cardiovascular diseases, Alzheimer's,autism,rheumatoid arthritis,pregnancy complications,leukemia,various neoplasms.
