Discover and read the best of Twitter Threads about #KetoMedStudy
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#KetoMedStudy: Nutrient Diffs
In our study we collected a lot of dietary data, primarily to characterize diets & report adherence
In supplemental tables we reported changes in NUTRIENTS on each diet phase
In this 🧵we share the nutrient changes
academic.oup.com/ajcn/article-l…
In our study we collected a lot of dietary data, primarily to characterize diets & report adherence
In supplemental tables we reported changes in NUTRIENTS on each diet phase
In this 🧵we share the nutrient changes
academic.oup.com/ajcn/article-l…
Two Diet Periods for each Diet Phase
Food Delivery
Self-Provided
For each 12-week phase of the study, participants received food deliveries for the first 4 weeks to maximize adherence.
For the next 8 weeks participants bought and prepared their own food (supported by staff)
Food Delivery
Self-Provided
For each 12-week phase of the study, participants received food deliveries for the first 4 weeks to maximize adherence.
For the next 8 weeks participants bought and prepared their own food (supported by staff)
Food Delivery Period
Supplement Table 8 from paper
Vitamins, minerals and fiber
Baseline
End of Food Delivery (week #4)
Absolute Standardized Differences (effect sizes) between diets for change from baseline.
~0.2 = small diff
~0.5 = moderate diff
~0.8 = large diff
Supplement Table 8 from paper
Vitamins, minerals and fiber
Baseline
End of Food Delivery (week #4)
Absolute Standardized Differences (effect sizes) between diets for change from baseline.
~0.2 = small diff
~0.5 = moderate diff
~0.8 = large diff
The results of the #KetoMedStudy are finally out! How low-carb do you need to go for glucose control? Is keto better than a low-carb Mediterranean diet with no refined grains (Med-Plus)? 👉 doi.org/10.1093/ajcn/n…
#keto #ketodiet #MediterraneanDiet #ketomedstudy #luciaaronica
#keto #ketodiet #MediterraneanDiet #ketomedstudy #luciaaronica
Here's a brief summary of the study and results:
Randomized, crossover trial of keto vs. Med-Plus (12-weeks for each diet phase) for glucose control in 33 individuals with pre-diabetes/diabetes.
Randomized, crossover trial of keto vs. Med-Plus (12-weeks for each diet phase) for glucose control in 33 individuals with pre-diabetes/diabetes.
Potential wins for keto:
• Lower CGM average glucose and TG with lower meds
• Lower HbA1c (primary outcome) after accounting for meds reduction
• Better outcomes with greater weight loss and higher HDL for those who started with Keto in the first phase
• Lower CGM average glucose and TG with lower meds
• Lower HbA1c (primary outcome) after accounting for meds reduction
• Better outcomes with greater weight loss and higher HDL for those who started with Keto in the first phase
#KetoMedStudy
Week #5
1/5
For past 4 wks, we've been sharing study design details of forthcoming Keto vs Mediterranean Study
This week, we want to share the 36-wk time point & get your thoughts.
Poll on next post in thread - vote on time point you think is most interesting 🤔
Week #5
1/5
For past 4 wks, we've been sharing study design details of forthcoming Keto vs Mediterranean Study
This week, we want to share the 36-wk time point & get your thoughts.
Poll on next post in thread - vote on time point you think is most interesting 🤔
2/5
Which is most interesting?
Adherence best at Wk #4 of each phase (food delivered)
⬆️rigor (efficacy)
Wk #12 of each phase
⬆️generalizabilty
36 wk - reality check (effectiveness)
Who is following what?
Which is most interesting?
Adherence best at Wk #4 of each phase (food delivered)
⬆️rigor (efficacy)
Wk #12 of each phase
⬆️generalizabilty
36 wk - reality check (effectiveness)
Who is following what?
3/5
Caveat
Primary outcome=HbA1c (ct.gov)
12wk Keto vs 12wk Med, relative to baseline
HbA1c not appropriate for assessing 4 wk change
We have Hba1c @ wks 0, 12, 24 & 36
We have CGM glucose @ wks 0, 4, 12, 16, 24
(Not enuf $$ to get CGM @ wk 36) 🙁
Caveat
Primary outcome=HbA1c (ct.gov)
12wk Keto vs 12wk Med, relative to baseline
HbA1c not appropriate for assessing 4 wk change
We have Hba1c @ wks 0, 12, 24 & 36
We have CGM glucose @ wks 0, 4, 12, 16, 24
(Not enuf $$ to get CGM @ wk 36) 🙁
1/9
Just completed trial
Keto vs Mediterranean
Just submitted Design & Adherence paper PRIOR to main results paper
While waiting for reviews & decision…
~10 weekly mini-threads - #KetoMedStudy
⬆️design understanding &
⬆️twitter civility?🙏
Week #1
Main study question
Just completed trial
Keto vs Mediterranean
Just submitted Design & Adherence paper PRIOR to main results paper
While waiting for reviews & decision…
~10 weekly mini-threads - #KetoMedStudy
⬆️design understanding &
⬆️twitter civility?🙏
Week #1
Main study question
2/9
US calories: 1999-2016
pubmed.ncbi.nlm.nih.gov/31550032/
Low quality carbs
Added sugars, refined grains: ~40%
High quality carbs (whole grains, legumes, fruits): ~10%
3 types fat: ~10% each
Protein: Animal ~10%; plant ~5%
***Biggest impact potential - ⬇️ low quality carbs
US calories: 1999-2016
pubmed.ncbi.nlm.nih.gov/31550032/
Low quality carbs
Added sugars, refined grains: ~40%
High quality carbs (whole grains, legumes, fruits): ~10%
3 types fat: ~10% each
Protein: Animal ~10%; plant ~5%
***Biggest impact potential - ⬇️ low quality carbs
3/9
Most/all healthy diet patterns recommend avoiding/minimizing added sugars & refined grains, while including non-starchy vegetables
Is there additional overall health benefit to also eliminating:
*Legumes/beans
*Whole intact grains
*Fruits
Poll next tweet
Most/all healthy diet patterns recommend avoiding/minimizing added sugars & refined grains, while including non-starchy vegetables
Is there additional overall health benefit to also eliminating:
*Legumes/beans
*Whole intact grains
*Fruits
Poll next tweet
