Discover and read the best of Twitter Threads about #Hydroxychlorquine
Most recents (2)
New trial of #hydroxychloroquine for #COVID from China. First thoughts:
1- It's a preprint on medRxiv - this means it has yet to be evaluated by the medical community and the information presented may be erroneous (read with a shaker of salt nearby)
medrxiv.org/content/10.110…
1- It's a preprint on medRxiv - this means it has yet to be evaluated by the medical community and the information presented may be erroneous (read with a shaker of salt nearby)
medrxiv.org/content/10.110…
2- That said, the research protocol was approved by proper Ethics Cmte at Renmin Hospital in Wuhan, research procedures follow Declaration of Helsinki & registered in Chinese Clinical Trial registry #hydrochloroquine #Covid_19
3- Randomized, double-blinded trial (nice!)
3- Randomized, double-blinded trial (nice!)
4- Added #hydrochloroquine (200mg 2x/day x 5days) to standard therapy (oxygen, antivirals, antibacterials, immunoglobulins +/- steroids)
5- Patients could not have severe/critical #Covid_19 infection; avg age was ~45y.o., even split M/F.
5- Patients could not have severe/critical #Covid_19 infection; avg age was ~45y.o., even split M/F.
Ppl ask, why not try #Hydroxychlorquine and #Azithromycin for #SARSCov2 #COVID19. Here is some important info to know about the study sciencedirect.com/science/articl…
1. 20 HCQ pts (200 mg TID) & 16 controls with SARSCoV2
2. Pts w/ URTI, LRTI, or asx
3. 6 HCQ pts received Azithro x 5 d
1. 20 HCQ pts (200 mg TID) & 16 controls with SARSCoV2
2. Pts w/ URTI, LRTI, or asx
3. 6 HCQ pts received Azithro x 5 d
4. Pts received Azithro to prevent bacterial superinfxn
5. At day 6 post-inclusion 70% of HCQ pts were virologically cured vs 12.5% in control
6. At day 6 100% (6 pts ) with HCQ+Azithro were virologically cured vs 57.1% of HCQ only (14 pts) vs 12.5% in control (16 pts)
5. At day 6 post-inclusion 70% of HCQ pts were virologically cured vs 12.5% in control
6. At day 6 100% (6 pts ) with HCQ+Azithro were virologically cured vs 57.1% of HCQ only (14 pts) vs 12.5% in control (16 pts)
Although this data is potentially promising there are a few things to consider
1. This study is not powered for efficacy
2. Small sample size
3. No long term follow-up (although virologically cured unknown if it returned)
4. Unclear info on pt co-morbidities who received drugs
1. This study is not powered for efficacy
2. Small sample size
3. No long term follow-up (although virologically cured unknown if it returned)
4. Unclear info on pt co-morbidities who received drugs
