Discover and read the best of Twitter Threads about #Glucocorticoids
Most recents (1)
🚫 DON’T use glucocorticoids in oxygen-free #COVID19 pts
Just published @NEJMEvidence
Guidelines are against glucocorticoids in pts not on O2 but effect on survival remains unclear
Our meta-analysis found that glucocorticoids increase mortality
🔗eviden.cc/3MnrDSA 1/5
Just published @NEJMEvidence
Guidelines are against glucocorticoids in pts not on O2 but effect on survival remains unclear
Our meta-analysis found that glucocorticoids increase mortality
🔗eviden.cc/3MnrDSA 1/5
2/
📝 STUDY SELECTION
P: adults with #COVID19 not receiving oxygen
I: intravenous or oral #glucocorticoids
C: any
O: all-cause mortality at the longest follow-up available
S: RCTs, matched studies
➡️ 5 RCTs and 1 propensity-matched study (total 6634 pts) were included
📝 STUDY SELECTION
P: adults with #COVID19 not receiving oxygen
I: intravenous or oral #glucocorticoids
C: any
O: all-cause mortality at the longest follow-up available
S: RCTs, matched studies
➡️ 5 RCTs and 1 propensity-matched study (total 6634 pts) were included
3/
🪦 MORTALITY: #Glucocorticoids vs comparator
14% vs 10% (OR=1.56; 95% CI=1.27 to 1.93)
Number needed to harm=27
Mortality increase was confirmed in RCTs only
16% vs 13% (OR=1.34; 95% CI=1.00 to 1.78)
Need for mechanical ventilation was also increased: 18% vs 15%
#FOAMcc
🪦 MORTALITY: #Glucocorticoids vs comparator
14% vs 10% (OR=1.56; 95% CI=1.27 to 1.93)
Number needed to harm=27
Mortality increase was confirmed in RCTs only
16% vs 13% (OR=1.34; 95% CI=1.00 to 1.78)
Need for mechanical ventilation was also increased: 18% vs 15%
#FOAMcc
