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Nicholas Ashton
@NicholasAshton
I am delighted to share our latest blood biomarker work published in @alzassociation.

We investigated baseline & longitudinal #pTau, #NfL, #GFAP, #tTau, #Aβ to predict diagnosis & grey matter changes in individuals not predetermined by CSF/imaging.

alz-journals.onlinelibrary.wiley.com/doi/full/10.10…

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2 - While all biomarkers were significantly changed in AD – only #pTau181 had a good accuracy in predicting AD dementia (AUC=0.91).

#pTau181 and #NfL were increased in MCI as compared to CU, and #pTau181 significantly increased in MCI converters versus non-converters ImageImage
3 - Comparing baseline plasma measures with longitudinal structural MRI, we observed that #pTau181, and to a lesser extent #Aβ, was significantly associated with GM loss. Image
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#GFAP #pTau181 #tTau #pTau #NfL #Aβ

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