Discover and read the best of Twitter Threads about #EHJ
Most recents (6)
Hot-of-the press sub-analysis of ADVOR trial looking at HCO3 levels and decongestive response @ESC_Journals #EHJ. A short 🧵 on the rational, findings and clinical translation of the paper. @FH_Verbrugge , @WilfriedMullens , @AlexMebazaa , @kevin_damman
doi.org/10.1093/eurhea…
doi.org/10.1093/eurhea…
The rational= old forgotten concept (fig). AT II stimulates prox nephron Na/HCO3. Exact stoichiometry might differ but per Na retained +/- 3 HCO3 are retained. HCO3 levels can indicate neurohormonal activation. HCO3 levels can predict development of HF (pubmed.ncbi.nlm.nih.gov/25896890/ ) 
If HCO3 levels in HF reflect prox nephron activation through NHE3 stimulation, patients might benefit more from decongestive effects of acetazolamide. + loop diuretics inhibit NKCC on macula densa ➡️ATII➡️HCO3 elevations during decongestion.
#Immunosuppressive therapy in virus-negative inflammatory CMP : 20-year follow-up of the #TIMIC trial
Immunosuppressive Tx of virus-negative inflammatory #CMP is associated to a persistent improvement of LV
function and better outcomes during long-term follow-up
#HeartFailure
Immunosuppressive Tx of virus-negative inflammatory #CMP is associated to a persistent improvement of LV
function and better outcomes during long-term follow-up
#HeartFailure
#Immunosuppressive Tx promoted an improvement in cardiac function in 88% of the cases compared the placebo group
A persistent ⤴️ in the #LVEF is seen in long -term (up to 20 years) clinical outcomes of the whole cohort of 85 patients originally enrolled in the #TIMIC trial
A persistent ⤴️ in the #LVEF is seen in long -term (up to 20 years) clinical outcomes of the whole cohort of 85 patients originally enrolled in the #TIMIC trial
Recurring virus-negative myocarditis responding to #immunosuppressive therapy
EKG showing LBBB (A) resolving after therapy (B)
(C and D) Echo apical view showing recovery of LV dysfunction from EF -28% ➡️ up to 51%
#HeartFailure #EchoFirst @ESC_Journals academic.oup.com/eurheartj/adva…
EKG showing LBBB (A) resolving after therapy (B)
(C and D) Echo apical view showing recovery of LV dysfunction from EF -28% ➡️ up to 51%
#HeartFailure #EchoFirst @ESC_Journals academic.oup.com/eurheartj/adva…
#EHRAtopicweek on device implantation techniques & peri-operative management
General considerations: Management of anticoagulation
1/4
#EHRA_ESC
General considerations: Management of anticoagulation
1/4
#EHRA_ESC
#EHRAtopicweek
BRUISE CONTROL:
A clinically significant pocket hematoma is an independent risk factor for subsequent device infection (HR 7.7).
@JACCJournals
bit.ly/3ocT2JU
2/4
BRUISE CONTROL:
A clinically significant pocket hematoma is an independent risk factor for subsequent device infection (HR 7.7).
@JACCJournals
bit.ly/3ocT2JU
2/4
#EHRAtopicweek
BRUISE CONTROL-2
- suggesting that either stopping or continuing non-vitamin K antagonist oral anticoagulants might be reasonable at the time of device implantation.
#EHJ @ESC_Journal bit.ly/3L1kyE8
3/4
BRUISE CONTROL-2
- suggesting that either stopping or continuing non-vitamin K antagonist oral anticoagulants might be reasonable at the time of device implantation.
#EHJ @ESC_Journal bit.ly/3L1kyE8
3/4
Educational Thread (longish) on AORTIC STENOSIS on the new #ESCGuidelines #ESCCongress published at @escardio #EHJ academic.oup.com/eurheartj/adva… Another thread to follow on AR. So truly excited about these guidelines and here’s why @mirvatalasnag @mmamas1973 @DrMarthaGulati @Hragy …/2
First things first #ESCCongress - a patient centered approach recommended. 👏 but I thought we had long moved to a patient centred approach but nonetheless good to highlight #epeeps #cardio #echofirst #whycmr …/3
#ESCCongress valve guidelines - and the role of the Heart Team re- emphasized. This is crucial. But also defining who should be present to constitute a ‘Heart Team’ @milena_mate @MelissaLyleMD @drzgezdentok1 @AScatteia @RositaZakeri @pacman8it @dr_benoy_n_shah @tchaaban1 …/4
#ESCCongress #ESCGuidelines This is a Long thread on Heart Failure Guidelines published @escardio #EHJ academic.oup.com/eurheartj/adva… LONG BUT EDUCATIONAL! Focus on CHRONIC HF #epeeps #CardioEd @AlexFrogoudaki @mmamas1973 @DrMarthaGulati @purviparwani @Filippatos @EkateriniL @Hragy …/2
#ESCCongress Firstly, no longer Mid Range, replace by MILDLY REDUCED LV EF. Makes a lot of sense - in fact for some time I thought the previous guidelines referred to ‘mildly reduced’ until @merinopoulos corrected me… otherwise no real change in the nomeculture …/3
#ESCCongress nice algorithm - assess risk factors… do BNPs (watch the caveats- AF ⬆️ , obesity ⬇️ value so bear this in mind. The #echofirst and classification into Reduced, mildly Reduced and Preserved. @SineadHughes19 @wordfinga @rahatheart1 @HEARTinMagnet @bp_halliday …/4
Our analysis of sex differences in the #YOUNG-MI registry is now published in #EHJ @ESC_Journals. See tweetorial below. A culmination of hard work with an incredible team of mentors @RonBlankstein @DLBHATTMD @DrMarthaGulati @SanjayDivakaran @drmalissawood
Of 2097 with first MI at young age, 19% were 🚺
🚺 were more likely to have diabetes, rheumatologic conditions and depression
🚺 had lower median incomes and higher rate of public insurance
Chest pain was the most common symptom in 🚺 and 🚹 with more atypical symptoms in 🚺
🚺 were more likely to have diabetes, rheumatologic conditions and depression
🚺 had lower median incomes and higher rate of public insurance
Chest pain was the most common symptom in 🚺 and 🚹 with more atypical symptoms in 🚺
🚺 were less likely to receive coronary angiography
Among those w/angiography, 🚺had ⬆️ SCAD, were more likely to have single vessel disease with lower aggregate plaque burden and ⬇️ revascularization
🚺 less likely to be discharged on ASA, beta blockers, ACE/ARB, and statins
Among those w/angiography, 🚺had ⬆️ SCAD, were more likely to have single vessel disease with lower aggregate plaque burden and ⬇️ revascularization
🚺 less likely to be discharged on ASA, beta blockers, ACE/ARB, and statins
