Discover and read the best of Twitter Threads about #DrugCosts
Most recents (4)
THREAD: Trama-DO or Trama-DON'T?
What to know about #tramadol
1/7 Tramadol has multiple mechanisms of action:
- via serotonin & norepinephrine reuptake inhibition
- after metabolism to M1 metabolite, via opioid agonism
bit.ly/3t5o7jC #chronicpain #arthritis #MedEd
What to know about #tramadol
1/7 Tramadol has multiple mechanisms of action:
- via serotonin & norepinephrine reuptake inhibition
- after metabolism to M1 metabolite, via opioid agonism
bit.ly/3t5o7jC #chronicpain #arthritis #MedEd
2/7 People metabolize #tramadol variably š¤š
- Some who are āultra rapidā produce more M1 (opioid);
- Some āpoorā metabolizers (~20% with inactive CYP2D6) may have more SSRI/SNRI-like effect
Thus, analgesic & adverse effects are unpredictable
ncbi.nlm.nih.gov/books/NBK315950 #MedEd
- Some who are āultra rapidā produce more M1 (opioid);
- Some āpoorā metabolizers (~20% with inactive CYP2D6) may have more SSRI/SNRI-like effect
Thus, analgesic & adverse effects are unpredictable
ncbi.nlm.nih.gov/books/NBK315950 #MedEd
3/7 Tramadol, once called a āsaferā opioid, causes tolerance and withdrawal, and is associated with addiction, overdose, and death
Observational studies show people treated with #tramadol, vs other opioids, are āļø likely to engage in prolonged opiate use #chronicpain #arthritis
Observational studies show people treated with #tramadol, vs other opioids, are āļø likely to engage in prolonged opiate use #chronicpain #arthritis
Daily Bookmarks to GAVNetĀ 11/20/2020 greeneracresvaluenetwork.wordpress.com/2020/11/20/daiā¦
Universal basic income helped Kenyans weather COVID-19 - but itās not a silver bullet
theconversation.com/universal-basiā¦
#UniversalBasicIncome #kenya #PandemicResponse #COVID19
theconversation.com/universal-basiā¦
#UniversalBasicIncome #kenya #PandemicResponse #COVID19
Amazon Pharmacy is a thing because we live in hell
mic.com/p/amazon-pharmā¦
#amazon #DrugCosts #MedicalCosts #healthcare #capitalism
mic.com/p/amazon-pharmā¦
#amazon #DrugCosts #MedicalCosts #healthcare #capitalism
Daily Bookmarks to GAVNetĀ 10/11/2020 greeneracresvaluenetwork.wordpress.com/2020/10/11/daiā¦
The Cure for Aging Might be the Cure for Alzheimerās - Andreessen Horowitz
a16z.com/2020/10/07/agiā¦
#alzheimer #cure #aging
a16z.com/2020/10/07/agiā¦
#alzheimer #cure #aging
Did indigenous Americans and Vikings trade in the year 1000? | Aeon Essays
aeon.co/essays/did-indā¦
#americans #vikings #trade
aeon.co/essays/did-indā¦
#americans #vikings #trade
THREAD: 5 Things You Need to Know About PPIs
For many years, we've dissected the research on Proton Pump Inhibitors (PPIs) š¤
This thread captures our publications on PPIs that can help you in clinical practice: ti.ubc.ca/?s=ppis
#MedEd #medsafety #DrugEvidence #GERD
For many years, we've dissected the research on Proton Pump Inhibitors (PPIs) š¤
This thread captures our publications on PPIs that can help you in clinical practice: ti.ubc.ca/?s=ppis
#MedEd #medsafety #DrugEvidence #GERD
2/6 PPI COSTS VARY CONSIDERABLY š°
Even without differences in efficacy or safety between PPIs, costs can vary x 10. The cheapest in BC? Pantoprazole Mg 40mg or Rabeprazole 10mg. Most expensive: Dexlanzoprazole
More here: ti.ubc.ca/letter99
#MedEd #DrugCosts #GERD
Even without differences in efficacy or safety between PPIs, costs can vary x 10. The cheapest in BC? Pantoprazole Mg 40mg or Rabeprazole 10mg. Most expensive: Dexlanzoprazole
More here: ti.ubc.ca/letter99
#MedEd #DrugCosts #GERD
3/6 RESPONSE IS VARIABLE
1 in 2 pts w/ acid reflux get symptom relief with a PPI (NNT~2) w/in 4-8 wks
Responders notice symptom relief w/in 1-9 days. If no relief in ~2 wks consider š PPI. Non-acid reflux doesnāt benefit from PPI
More here: ti.ubc.ca/letter99
#MedEd
1 in 2 pts w/ acid reflux get symptom relief with a PPI (NNT~2) w/in 4-8 wks
Responders notice symptom relief w/in 1-9 days. If no relief in ~2 wks consider š PPI. Non-acid reflux doesnāt benefit from PPI
More here: ti.ubc.ca/letter99
#MedEd
