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Danish Saleheen stunned the audience with his story of building the world's largest cohort of human knockouts in Pakistan, which is the world's 5th most populous country with highest level of consanguinity ever known. #ASHG22 #DRIFT22 
Starting with around 10k individuals sequenced in 2017, now the cohort comprise of around 200k individuals recruited, of which 80,000 were exome sequenced. Goal is to sequence 1 Million.
nature.com/articles/natur…
nature.com/articles/natur…
Based on these data, they have identified so far >14000 human knockouts for >5000 genes. To achieve the same in European populations, you'll have to sequence >11 million individuals.
