Discover and read the best of Twitter Threads about #CompositeOutcome
Most recents (1)
Choosing the right outcome is key to a clinical trial. Sometimes a #CompositeOutcome
- an outcome that combines more than one dimension into a single measure - is felt to be most appropriate. These can be useful but can be fraught with difficulty 1/8
#MethodologyMonday
- an outcome that combines more than one dimension into a single measure - is felt to be most appropriate. These can be useful but can be fraught with difficulty 1/8
#MethodologyMonday
One of the primary reasons for using a composite outcome is trial efficiency - you can get more events quickly compared to the individual components thus increasing precision and efficiency in sample size calculations 2/8
jamanetwork.com/journals/jama/…
jamanetwork.com/journals/jama/…
However, the validity of a composite relies on consistency of the individual components -see Montori et al 3/8
bmj.com/content/330/74…
bmj.com/content/330/74…
