Discover and read the best of Twitter Threads about #Big10
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New preprint showing a #SARSCoV2 nucleocapsid variant that impacts antigen test performance. One sample just didn't want to play ball with the Quidel SARS Antigen FIA, of #pac12 and #big10 fame. So we sequenced it...
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
Using additional clinical specimens and recombinant nucleocapsid, we mapped to D399N. Looks like a ~1000-fold effect on assay performance. Doesn't affect Quidel QuickVue or BinaxNOW. This is a rare mutation, occurring in 0.02% global genomes. But variants are everywhere.
big thanks to @GAPerchetti for initially pulling this thread and Jon Reed and Quynh Phung in the lab for recombinant work, Michelle Lin for data viz, Dr. Lori Bourassa for coordination and @DrKimHarmon for the initial tests.
#Big10 football players will be tested daily for #COVID19. Many meatpacking plant employees—declared essential workers by the federal government—in the Big 10 region can't get adequate testing for themselves or their families. Some have been denied testing by local governments.
According to @leahjdouglas's daily tally: 52,018 meatpacking and food processing workers have contracted #COVID19 and 237 of those workers have died. Their "hero pay" has expired, and even at-risk workers are being called back to work—or will face firing. thefern.org/2020/04/mappin…
At a hearing before the Nebraska Legislature last month, workers at major packing plants reported that they receive one surgical mask per day—and it is soaked with blood within the first 2 hours of their shifts. That has not changed.
So the German JAMA #COVID19 cardiology study that has been referenced thousands of times to shut down the #Big10 and #PAC12 seasons by media including @ESPN presents data that is statistically impossible. Basically everything in this table below is bogus. Let me explain: 
For this example I'm going to use systolic blood pressure but it can be anything that was highlighted above by @ProfDFrancis. In the table above, the parentheses mean they found an interquartile range for systolic BP of 125-133 - or 50/100 of their subjects fell in this range.
This is a problem. In a much larger study across the German population the IQR is much larger. For example, if we take the 41-50 age range from this larger study (similar range to the JAMA study) they found a mean of 130.5 and a standard deviation of 16.8.
