Discover and read the best of Twitter Threads about #AnemiaRegion
Most recents (2)
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π€βDonβt make a change too complicated, just begin.β
π We have a chance to make a βchange for goodβ in anemia Rx in CKD.
π₯Letβs discuss hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs), the probable championsπ of NephMadness 2021. #AnemiaRegion
π€βDonβt make a change too complicated, just begin.β
π We have a chance to make a βchange for goodβ in anemia Rx in CKD.
π₯Letβs discuss hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs), the probable championsπ of NephMadness 2021. #AnemiaRegion
2/ πHypoxia Inducible Factor (HIF) - Physiology
- Present in all tissues.
- Has O2 regulated πͺ (3 isoforms) and constitutively expressed π subunits.
- HIF-2πͺ is expressed in the peritubular fibroblasts, mainly involved in the upregulation of EPO gene.
- Present in all tissues.
- Has O2 regulated πͺ (3 isoforms) and constitutively expressed π subunits.
- HIF-2πͺ is expressed in the peritubular fibroblasts, mainly involved in the upregulation of EPO gene.
3/
ποΈβ Hypoxia, HIF πͺ heterodimerizes with π subunit in the nucleus β the complex binds with DNA sequences called hypoxia response elements β Gene activation β β RBC production by β essential protein synthesis linked with iron and EPO pathways. mdpi.com/1422-0067/19/2β¦
ποΈβ Hypoxia, HIF πͺ heterodimerizes with π subunit in the nucleus β the complex binds with DNA sequences called hypoxia response elements β Gene activation β β RBC production by β essential protein synthesis linked with iron and EPO pathways. mdpi.com/1422-0067/19/2β¦
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It has been more than a century tackling Anemia in CKD since its first description by Richard Bright in 1835.
π #NephMadness 2021 is featuring strong contenders from the #AnemiaRegion.
π€ Let's find out why Anemia in CKD is an important consideration. #NSMCInternship
It has been more than a century tackling Anemia in CKD since its first description by Richard Bright in 1835.
π #NephMadness 2021 is featuring strong contenders from the #AnemiaRegion.
π€ Let's find out why Anemia in CKD is an important consideration. #NSMCInternship
2/π What % of patients with CKD stage 4 have anemia based on KDOQI (Hb <13.5 g/dL for men and <12.0 g/dL for women) and WHO (<13.0 g/dL for men & <12.0 g/dL for women)?
3/
π³ Around 60% of the patients with stage 4 CKD not on dialysis have anemia based on KDOQI/WHO.
π Anemia contributes to significant morbidity in patients with CKD.
pubmed.ncbi.nlm.nih.gov/18359408/
π³ Around 60% of the patients with stage 4 CKD not on dialysis have anemia based on KDOQI/WHO.
π Anemia contributes to significant morbidity in patients with CKD.
pubmed.ncbi.nlm.nih.gov/18359408/
