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2 more NEGATIVE studies of #VitaminC in #sepsis: #ACTS in @JAMA_current & #ATESS in @yourICM.
It' doesn’t look good for the "metabolic cure”
5/6 negative for 1° endpoints; ORANGES found ⬇️ pressor use
5/6 with no mortality Δ; CITRIS did, but mortality was 1 of 46 2° endpoints
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It' doesn’t look good for the "metabolic cure”
5/6 negative for 1° endpoints; ORANGES found ⬇️ pressor use
5/6 with no mortality Δ; CITRIS did, but mortality was 1 of 46 2° endpoints
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This is a great time to do some meta-analysis.
As you can see from my quick/simple analysis, neither vitamin C either alone or in combination with hydrocortisone and steroids reduced in mortality in people with sepsis:
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As you can see from my quick/simple analysis, neither vitamin C either alone or in combination with hydrocortisone and steroids reduced in mortality in people with sepsis:
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What about other endpoints? It doesn't look much better for vitamin C: 4/6 found no ΔSOFA scores.
Also, while ΔSOFA scores and duration of vasopressors are important, I would argue that mortality is a more meaningful (and more patient centered) endpoint.
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Also, while ΔSOFA scores and duration of vasopressors are important, I would argue that mortality is a more meaningful (and more patient centered) endpoint.
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