Discover and read the best of Twitter Threads about #ASH19
Most recents (12)
With #ASH20 around the corner, I wanted to share a summary of the major myeloma immunotherapy - CARs, Bispecifics, ADCs trials and #ASH20 abstracts to look out for #mmsm from a recent talk I gave bmj.com/content/370/bm…
I will focus on some of the major drugs in this thread (in the blue boxes). Although I may not be able to cover all of them, the trials I have typed over the image are the ones to watch out for at #ASH20 
We will see updates at #ASH20 for cilta-cel (JNJ-4528) and P-BCMA 101. We will see subgroup analyses and correlative data for KarMMa and EVOLVE studies.
WHAT IS THE RISK CLASSIFICATION OF THE t(11;14) in MM?
This has been a long-debated question and probably asked in the wrong way. I have always had a special interest in the t(11;14) and want to tell a story and how it relates to venetoclax.
#mmsm #ASH19
1/x
This has been a long-debated question and probably asked in the wrong way. I have always had a special interest in the t(11;14) and want to tell a story and how it relates to venetoclax.
#mmsm #ASH19
1/x
In 1998 we reported the t(11;14) was a poor prognostic marker (only translocation visible in karyotypes). We were seeing the effect of abnormal karyotypes- more growth and tumor burden. @VincentRK
onlinelibrary.wiley.com/doi/full/10.10…
ncbi.nlm.nih.gov/pubmed/10459351
2/x
onlinelibrary.wiley.com/doi/full/10.10…
ncbi.nlm.nih.gov/pubmed/10459351
2/x
That year I convinced M Gertz to send me to Leiden, Netherlands to study t(11;14) via fiber-FISH- most elegant FISH assay. Only achievable by the great Dutch masters. At my return M Kuehl said “stop wasting your time & start doing interphase FISH.” Best advice!
@MorieGertz
3/x
@MorieGertz
3/x
Blown away by rising star @mwschoen's masterful storytelling of how he is trying to understand and eradicate racial disparities in myeloma treatment and outcomes...
file:///var/folders/mw/0w9f93f97wscrp764dmz0k900000gp/T/com.apple.iChat/Messages/Transfers/IMG_6462.jpeg #ASH19
file:///var/folders/mw/0w9f93f97wscrp764dmz0k900000gp/T/com.apple.iChat/Messages/Transfers/IMG_6462.jpeg #ASH19
@mwschoen Dr. Schoen walks us through a hypothesis that renal impairment and racial differences in estimating renal function may impact treatment and outcome: 1) Pts with renal dies less likely to receive lenalidomide.
@mwschoen 2) Black veterans have higher creatinine but better GFR... if clinician only looks at creatinine, may err in understanding pts renal function.
Abs 380: Geriatric assessment incorporated into a real transplant workflow. Took only 5-6 minutes of provider time! And see thread for what that 5-6 min tells you...
#ASH19 #geriheme grants.nih.gov/grants/guide/p…
#ASH19 #geriheme grants.nih.gov/grants/guide/p…
Survival: lower OS with impairment on Timed Up and Go
Here's my #gerihemelist for #ASH19 Saturday...
Abs 2209, Poster today: 1/3 of pts with "good" PS were frail; Frail pts with AML had 50% 100-day mortality! ash.confex.com/ash/2019/webpr…
Abs 1563, poster today: In SEER-Medicare analysis of 2800 older adults with Hodgkin Lymphoma (1999-2014), 1/4 received NO treatment.
#ASH19 #geriheme ash.confex.com/ash/2019/webpr…
#ASH19 #geriheme ash.confex.com/ash/2019/webpr…
Abs 268: @HiraSMian presents data on >5700 pts with MM from Canadian registry with some good/some sobering news for #geriheme pts:
1. ASCT use rising
2. 60% of older pts get a novel drug
3. 20% 1-yr mortality
4. 30% of older patients received NO MYELOMA TREATMENT
#ASH19
1. ASCT use rising
2. 60% of older pts get a novel drug
3. 20% 1-yr mortality
4. 30% of older patients received NO MYELOMA TREATMENT
#ASH19
Even with universal coverage, older pts, lower SES or more comorbidities less likely to be treated for myeloma #mmsm #geriheme #ASH19
High 1-yr mortality for older pts with myeloma who don’t receive treatment. We saw similar rate untreated in SEER- Medicare database. #geriheme ncbi.nlm.nih.gov/m/pubmed/29429…
Abs 71: Trends in early mortality (<6 mos) in myeloma - SEER analysis of >90K pts 1975-2015 with Joinpoint regression -> change in trend for early mortality.
ash.confex.com/ash/2019/webpr…
#mmsm #ASH19
ash.confex.com/ash/2019/webpr…
#mmsm #ASH19
Older pts with MM at greater risk for early mortality (OR 4.8 for Age >79).
#geriheme
#geriheme
Abs 69: Vulnerable Elders Survey-13 in cohort of >2000 patients in the Lymphoma Epidemiology Outcome cohort.
28% of pts were vulnerable by VES13. Pts more likely to be vulnerable if they completed VES13 after treatment
ash.confex.com/ash/2019/webpr… #ASH19 #geriheme @MaurerStats
28% of pts were vulnerable by VES13. Pts more likely to be vulnerable if they completed VES13 after treatment
ash.confex.com/ash/2019/webpr… #ASH19 #geriheme @MaurerStats
@MaurerStats Vulnerable pts had poorer OS (HR ~5) *** independent of performance status***. PS is not enough! #ASH19 #geriheme
@MaurerStats Moderator question: How to use this info? Answer: good tool to screen for need for geriatric assessment
Abstract 67: all new patients with blood cancer age >=75 screened for frailty; participants randomized to receive geriatric consultation. Outcomes: feasibility, 1-yr OS, acute care utilization, goals of care discussion. ash.confex.com/ash/2019/webpr…
At last the BIG reveal! Every @ASH_hematology member dreams of telling their kid YOU’RE GOING TO #ASH19! Not all @Disney princesses wear crowns...#WomenInSTEM #FutureHematologist
“Should we go to the @ASH_hematology conference?” #ASH19
Don’t miss @cohesinlab today 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Transcriptional Dysregulation via Chromatin 3D Structure 4:00 PM - 5:30 PM Room: W340 #ASH19
#HematologyTweetstory 10: how did the 5 major #nucleobases get their names? This is slightly tangential to hematology, admittedly, but is a cool story that I’ve been aching to tell since I went through an intense etymology phase many years ago (still have lots of dusty books)./1
#Guanine is probably the most interesting of the 5. It was first isolated in 1846 from guano, i.e. bird crap, by German chemist Julius Bodo Unger (1819-1885), who studied with the famous Justus Liebeg in Gießen. Unger later owned a factory in #Hannover. Guano image from JSTOR./2
It is hard to imagine just how important seabird guano was economically, back before the beginning of the 20th century when Fritz Haber (who favored #PelgerHuet style eyeglasses😉) figured out how to fix nitrogen artificially & make ammonia. Guano was used for fuel, fertilizer./3
1. 2 out of 5 real-world myeloma patients ineligible for clinical trials; 75% of frail patients ineligible.
ash.confex.com/ash/2019/webpr…
#GeriHemeList
ash.confex.com/ash/2019/webpr…
#GeriHemeList
2. Response rates in frail patients similar to those in intermediate or fit transplant-ineligible NDMM patients
ash.confex.com/ash/2019/webpr…
#GeriHemeList
ash.confex.com/ash/2019/webpr…
#GeriHemeList
