Discover and read the best of Twitter Threads about #AIV

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Happy to announce that the full genome sequence of the Cambodian #H5N1 #avianflu case is now available on @GISAID. This has been an incredible effort by a number of people: (1/)
We were able to go from original sample to full genome sequence in <24 hours using iMS-PCR from @peter_thielen from @JHUAPL on @oxfordnanopore #ONT technology @nanopore #nanopore using capacity developed before and during the #COVID19 pandemic (2/)
This information is critical in our understanding of this case as Clade 2.3.2.1c #avianinfluenza viruses have been endemic in Southeast Asia for ~10 years and human-human transmission ability has not been established. (3/)
Read 5 tweets
1. How does SARS cause AIDS?

The virus SARS-CoV causes systemic chronic immune activation, loss of plasmacytoid dendritic cells (pDC), naive T and B cells, and acquired immunodeficiency syndrome (AIDS)

I would propose the name airborne immunodeficiency virus (#AIV) #SIDU 221225 Image
2. COVID19 (SARS) is transient because the virus clears as epithelial cells regenerate. It extends the infected cell's life (500-787 days in the renal epithelium). It causes #AirborneAIDS in SARS survivors; hence the need for #ZEROairborneAIDS (#ZeroCOVID)
3. Immune damage acquired from SARS (Covid) can be premanent

What causes SARS-associated chronic immune activation? - @fitterhappierAJ published early and warned the public most consistently. We all owe him
frontiersin.org/articles/10.33…
mdpi.com/2076-0817/11/4…
frontiersin.org/articles/10.33…
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