Discover and read the best of Twitter Threads about #2deoxy2glucose
Most recents (2)
1
Im quoted in report on #2DG, drug by #DRDO, marketd by #DRreddys 4 #CovidIndia. Issues R well highlightd by @neutranino in @the_hindu 'Repurposed' use is questionable
This 'approval' doesnt bring ray of hope, but doubts on drug regulation in #india
A🧵
thehindu.com/news/national/…
Im quoted in report on #2DG, drug by #DRDO, marketd by #DRreddys 4 #CovidIndia. Issues R well highlightd by @neutranino in @the_hindu 'Repurposed' use is questionable
This 'approval' doesnt bring ray of hope, but doubts on drug regulation in #india
A🧵
thehindu.com/news/national/…
2
#2deoxy2glucose is basically glucose molecule in wich 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis (which is the metabolic pathway that converts glucose to pyruvate and a hydrogen ion, during which, the free energy released in process...
#2deoxy2glucose is basically glucose molecule in wich 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis (which is the metabolic pathway that converts glucose to pyruvate and a hydrogen ion, during which, the free energy released in process...
3...is used to form high-energy molecules such as ATP or NADH that helps in various cell functions). So basically, by using 2DG, the normal glycolysis doesnt happen and cell functions get blocked. This is the reason it is used for cancers
Cancer cells depend heavily on glucose...
Cancer cells depend heavily on glucose...
1/5
Whole premise of #2deoxy2glucose is based on this SINGLE computational proteomics study nature.com/articles/s4158…
No human trials until nw
1 of 'targets' hypothesized in reviews nature.com/articles/s4225…
Last human trials on this molecule is from 1982-2007
@drcheruvarun @pash22
Whole premise of #2deoxy2glucose is based on this SINGLE computational proteomics study nature.com/articles/s4158…
No human trials until nw
1 of 'targets' hypothesized in reviews nature.com/articles/s4225…
Last human trials on this molecule is from 1982-2007
@drcheruvarun @pash22
2/5
'Hypothesis' #Covid19 promot defective glucose metabolism (shown in controversial study pubmed.ncbi.nlm.nih.gov/32697943/) never clinically proven tho. Low-glucose mimetic (2DG) reduces tis, wit additional anti inflammatory/interaction wit viral proteins - again, cell study
#MedTwitter
'Hypothesis' #Covid19 promot defective glucose metabolism (shown in controversial study pubmed.ncbi.nlm.nih.gov/32697943/) never clinically proven tho. Low-glucose mimetic (2DG) reduces tis, wit additional anti inflammatory/interaction wit viral proteins - again, cell study
#MedTwitter
3/5
The anti-inflammatory/antiviral effect is thot 2 B due to glucose switching of 2GD - reversal of aerobic glycolysis to oxidative phosphorylation - is also in-silico study - not comprehensively shown in cell models.
tandfonline.com/doi/full/10.10…
@drreddys jumped the gun quickly.
The anti-inflammatory/antiviral effect is thot 2 B due to glucose switching of 2GD - reversal of aerobic glycolysis to oxidative phosphorylation - is also in-silico study - not comprehensively shown in cell models.
tandfonline.com/doi/full/10.10…
@drreddys jumped the gun quickly.
